TBL Immunity And Response Flashcards
Which of the following statements about chicken pox (varicella, caused by Varicella-Zoster Virus - VZV) is incorrect?
A. Initially during infection VZV proliferates in the oral pharynx (tonsils)
B. Innate immunity plays no role in protection against VZV
C. Once the child has recovered from the VZV infection the virus remains latent (present but inactive) in neurons
D. Rare complications of varicella in children include encephalitis and haemorrhage
E. T cells can become infected, and these disseminate virus t
B. Innate immunity plays no role in protection against VZV
Infection of children with Varicella-Zoster Virus (VZV) typically leads to which one of the following?
A. Cytotoxic T cells specific for VZV antigen presented in MHC class II context
B. Helper T cells expressing T cell receptors (TCR) that bind to VZV antigens presented to them by dendritic cells in MHC class II context
C. T cells specific for VZV antigens but no B cell response
D. The adaptive immune system is not capable of responding to VZV in children
E. VZV-specific antibodies but no T cell response
B. Helper T cells expressing T cell receptors (TCR) that bind to VZV antigens presented to them by dendritic cells in MHC class II context
Children are not normally vaccinated against Varicella-Zoster virus (VZV) because..?
A. Infection is so uncommon that the vaccine would have little effect
B. No effective vaccine exists
C. The vaccine is too expensive to produce, distribute and administer
D. Vaccines can be dangerous and often cause complications like autoimmunity
E. Varicella in children is usually self-limit
E. Varicella in children is usually self-limit
Which of the following statements relating to the disease shingles (herpes zoster, caused by Varicella-Zoster Virus - VZV) is true?
A. A child who has not yet been infected with VZV can catch shingles from an infected person
B. Even if someone has previously had a VZV infection, the chicken pox vaccine can still protect against developing shingles
C. Shingles is more likely to occur in immunocompromised older patients
D. Shingles only occurs in people who have not been previously infected with VZV as a child
E. Shingles results when d
C. Shingles is more likely to occur in immunocompromised older patients
Which of the following statements about B cell responses to Varicella-Zoster Virus (VZV) is incorrect?
A. Antibodies can bind specifically to VZV and block its attachment to the receptor used to infect target cells
B. Antibodies to VZV will effectively target virus that has penetrated to the cytosol of an infected cell
C. B cells can produce antibodies that bind to VZV surface antigens
D. Once an infection with VZV has been cleared, memory B cells that recognise VZV antigens are likely to remain for many years
E. The B cells that are activated as a
B. Antibodies to VZV will effectively target virus that has penetrated to the cytosol of an infected cell
Which of the following statements about T cell responses to Varicella-Zoster (VZV) is incorrect?
A. CD4+ helper T cells are capable of recognising antigens that are processed and presented through the endogenous pathway
B. CD4+ helper T cells are capable of recognising VZV antigens presented in MHC class II context
C. CD4+ helper T cells play an important role in coordinating adaptive immune responses to VZV
D. CD8+ cytotoxic T cells are capable of recognising VZV antigens that are processed through the endogenous pathway
E. On receiving the correct signals, CD8+
A. CD4+ helper T cells are capable of recognising antigens that are processed and presented through the endogenous pathway
