TB Drug Mechanisms Flashcards
0
Q
Blocks RNA polymerase and mRNA elongation
A
Rifampin
1
Q
Cell wall synthesis inhibitor, inhibits mycolic acid synthesis. Gets activated by bacterial catalase peroxidase into active form.
A
Isoniazid
2
Q
Prevents formation of ribosome complex, causes early termination of mRNA translation
A
Streptomycin
3
Q
Disrupts cell membrane metabolism and transport. Works best in acidity.
A
Pyrazinamide
4
Q
Inhibits arabinosyl transferase, blocks aribinoglycan formation (cell wall)
A
Ethambutol
5
Q
B6 form used to treat toxicity
A
Pyradoxine
