Autonomic Drugs

Question 0

Where are most nicotinic receptors?

Answer 0

Skeletal muscle

Question 1

What three drug classes cause bronchoconstriction?

Answer 1

Beta blockers
Muscarinic agonists
Anticholinesterases

Question 2

What are alpha 1 receptors coupled to in the cell?

Answer 2

Phospholipase C (DAG, IP3)

Question 3

What are three functions of the beta 2 receptor?

Answer 3

Vasodilate
Bronchodilate
Glycogenolysis

Question 4

What drug do you give to test for asthma?

Answer 4

Methacholine

Question 5

What is the intracellular role of the muscarinic receptor?

Answer 5

Activates phospholipase C

Decreases cAMP

Question 6

What is the Gi-a receptor and what does it stimulate?

Answer 6

Phospholipases

inhibits cAMP

Question 7

What do Gs-alpha receptors stimulate?

Answer 7

cAMP formation

Question 8

What do Gq-alpha receptors stimulate?

Answer 8

phospholipase C

Question 9

What three asthma medicines are first lines of defense? What is their MOA?

Answer 9

Albuterol, metaproterenol, terbutaline

B2 agonists

Question 10

What LABA should we know?

Answer 10

Salmeterol

Question 11

What are major side effects of beta agonists?

Answer 11

Tachycardia/palpitations
Tremor
Headache

Question 12

Why should you be wary in using beta agonists too much?

Answer 12

Lose effect if used too much

Question 13

What should epinephrine be used for?

Answer 13

Acute Bronchospasm in asthma

Anaphylaxis and hypersensitivity

Question 14

How does ephedrine work and what are its effects?

Answer 14

Increases norepinephrine spill into synapse

Increases bronchodilation and vasoconstriction

Question 15

What is the mechanism of action of phenylephrine?

Answer 15

A1 receptor agonist

Question 16

What drugs are alpha antagonists and what is the effect on the lungs?

Answer 16

Phentolamine, Phenoxybenzamine, Terazosin, Prazosin

Cause increase in mucous buildup

Question 17

What is the most likely mechanism for ipratropium treatment of COPD?

Answer 17

Bronchodilation

Mucous reduction