Antibiotics - Mechanisms

Question 0

Pipiracillin, Tazobactam

Answer 0

Binds to penicillin binding protein, inhibits cell wall transpeptidation

Question 1

Penicillin

Answer 1

Bind to penicillin binding protein, inhibit cell wall transpeptidation

Question 2

Doxycycline

Answer 2

Bind to 30s Ribosome, prevents attachment of tRNA

Question 3

Cephalosporins

Answer 3

Binds to penicillin binding protein, inhibits cell wall transpeptidation

Question 4

Azithromycin

Answer 4

Bind to 23s rRNA of 50s Ribosome to prevent translocation

Question 5

Amoxicillin

Answer 5

Binds to penicillin binding protein, inhibits cell wall transpeptidation

Question 6

Clarithromycin

Answer 6

Binds to 23s rRNA of 50s subunit of ribosome to prevent translocation

Question 7

Fluoroquinolones (floxacin)

Answer 7

Inhibits topo II and IV, inhibits cellular replication (cidal)

Question 8

Carbapenems

Answer 8

Binds to penicillin binding protein, inhibits cell wall transpeptidation

Question 9

Polymyxin E

Answer 9

Binds phosphatidylethanolamine and tears holes in membrane

Question 10

Vancomycin

Answer 10

Binds to D-Ala D-Ala dipeptide and inhibits transglycosylation

Question 11

Linezolid

Answer 11

Binds to ribosome and inhibits translation

Question 12

Amphoteracin B

Answer 12

Binds ergosterol and tears holes in the membrane of fungi

Question 13

Oseltamavir

Answer 13

Neuraminidase inhibitor

Question 14

Voriconazole

Answer 14

Binds ERG11, preventing synthesis of ergosterol and leading to increased levels of toxic sterols

Question 15

Itraconazole

Answer 15

Binds ERG11, preventing synthesis of ergosterol and leading to increased levels of toxic sterols

Question 16

Zanamivir

Answer 16

Neuraminidase inhibitor

Question 17

Aztreonam

Answer 17

Binds to penicillin binding protein, inhibits cell wall transpeptidation
Single ring, resistant to beta lactamase