Tayside Antibiotic Man

Question 1

empirical therapy for meningitis

Answer 1

ceftriaxone IV 2g BD + dexamethasone IV 10mg QDS

Question 2

what is added in meningitis if

• immunocompromised
• over 60 years old

Answer 2

amoxicillin IV 2g 4 hourly

Question 3

treatment of suspected encephalitis

Answer 3

IV aciclovir 10mg/Kg/Hour

Question 4

empirical therapy for epiglottitis

Answer 4

ceftriaxone IV 2g od

Question 5

tx CURB65 0-2 (mild CAP)

Answer 5

amoxicillin 1g tds for 5 days

- doxycycline if allergic

Question 6

tx CURB65 3-5 (severe CAP)

Answer 6

IV co-amoxiclav + clarithromycin 7 days

- IV levofloxacin if allergic

Question 7

tx mild HAP

Answer 7

amoxicillin for 5 days

- doxycycline if allergic

Question 8

tx severe HAP

Answer 8

IV amoxicillin + gentamicin for 7 days

- IV co-trimoxazole + gentamicin if allergic

Question 9

therapy for aspiration pneumonia

• mild
• severe

Answer 9

mild- oral amoxicillin + metronidazole
severe - IV amoxicillin + metronidazole + gentamicin
— replace amoxicillin with doxycycline if allergic

Question 10

empirical therapy acute exacerbation of COPD

Answer 10

amoxicillin 500mg tds

Question 11

tx for subacte native valve endocarditis

Answer 11

IV amoxicillin + gentamicin

Question 12

tx for acute native valve endocarditis

Answer 12

IV flucloxacillin

Question 13

tx for prosthetic valve endocarditis

Answer 13

IV vancomycin + Gentamicin + rifampicin

Question 14

tx non severe C.Diff infection

Answer 14

metronidazole 400mg tds for 10 days

Question 15

tx severe C.Diff infection

Answer 15

vancomycin +/- metronidazole for 10 days

Question 16

broad spectrum treatment for peritonitis / biliary tract infection / intra-abdominal infection

Answer 16

IV amoxicillin + metronidazole + gentamicin (7 days)

- step down therapy: co-trimoxazole + metronidazole

Question 17

when should antibiotics be given to catheterised patients with suspected UTI?

Answer 17

only if clinical signs/symptoms of UTI

- do not go off urinalysis result if asymptomatic

Question 18

how long is uncomplicated UTI treatment for

• females
• males

Answer 18

females = 3 days
males = 7 days

Question 19

tx options for uncomplicated UTIs

Answer 19

nitrofurantoin

trimethoprim

Question 20

tx for UTI pregnant woman in

• 1st trimester
• 3rd trimester

Answer 20

1st = nitrofurantoin 
3rd = trimethoprim

Question 21

empirical therapy for pyelonephritis

Answer 21

IV amoxicillin + gentamicin

Question 22

empirical therapy for open fracture prophylaxis

Answer 22

IV co-amoxiclav

- IV co-trimoxazole + metronidazole if allergic

Question 23

empirical therapy for cellulitis

Answer 23

Flucloxacillin