Targets for anti-emetics- 16 Flashcards
1
Q
What are examples in vomiting of opening pharmacological doors with molecular keys.
A
- Acetylcholine binding to mAch in the vomiting centre in the vestibular nuclei to cause sickness
- Histamine binding to the H1 receptor in the vestibular nuclei.
2
Q
Why does cinnarizine bind in a slightly different position.
A
Due to lipophillic interactions.
3
Q
What do cinnarizine and promethazine retain for essential activity.
A
Retains aromatic rings and tertiary N groups.
