Design Of Pain Medications- 8

Question 1

What are NSAID’s used to treat

Answer 1

Pain and Inflammation

Question 2

What is the mechanism of action of NSAID’S

Answer 2

They act as non-selective reversible inhibitors of the enzyme cyclooxygenase.

They reduce levels of chemicals called prostaglandins involved in inflammation by blocking their synthesis from arachidonic acid by COX enzymes.

Question 3

Chemical Structure and Mechanism of Action of Aspirin

Answer 3

Aspirin is one of the salicylates.

It irreversibly inhibits COX-1
This unique behaviour allows aspirin to inhibit platelet aggregation.

Question 4

Chemical Structure and Mechanism of Action of Ibuprofen

Answer 4

It is a propionic acid derivative

It acts as a nonselective COX 1+2 inhibitor

Question 5

Chemical structure and mechanism of action of diclofenac

Answer 5

Acetic acid derivative

It is a non-selective COX 1+2 inhibitor

Question 6

Mechanism of action and examples of coxibs

Answer 6

Celecoxib
Parecoxib
Etoricoxib

Selective COX-2 inhibitors