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Ceutics- packet 1 > Tablets > Flashcards

Tablets Flashcards

1
Q

two types of solid dosage forms

A

disintegrating type

non-disintegrating type

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2
Q

Oral Tablets for Ingestion

A 
Compressed tablets
Multiple compressed tablets
Chewable tablets
Fast dissolving tablets
Delayed action and enteric coat tablets
Sugar and chocolate coated tablets
Gelatin coated tablets
Molded tablets
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3
Q

Advantages of Tablets

A 
Accurate dosage 
Convenient
Can be scored or coated
Easy to administer
Control release of active
Economical to manufacture
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4
Q

Disadvantages of Tablets

A

Mistaken as candy
Formulation sometimes limited
Not useful of vomiting/unconscious patients
Difficulty swallowing

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5
Q

Components of a Tablet

A

Active ingredient

Excipients

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6
Q

Excipients used for tablet

A 
Diluents/ fillers
Binders
Lubricants
Gildants
Anti-adherents
Disintegrants
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7
Q

Provide bulk to a tablet formulation
Good compaction properties
Flow properties

A

Diluents or Fillers

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8
Q

Examples of Diluents or Fillers

A

Lactose USP
Microcrystalline cellulose
Modified dextrose

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9
Q

Factors Influencing Choice of Fillers

A 
Compressibility
Flowability
Particle size and distribution
Moisture content
Bulk density
Compatibility with active
Solubility 
Stability
Cost/availability
Inertness
Governmental acceptability
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10
Q

Promote adhesion of powder particles
Its concentration affects hardness and friability of tablet
Dry or liquid state

A

Binders

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11
Q

examples of binders

A 
Starch
Polyvinylpyrrolidone (PVP)*
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12
Q

Promotes break-up of tablet into smaller pieces after it has been swallowed

A

Disintegrating Agents

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13
Q

Disintegrating Agents Mechanism

A

absorb water and swell

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14
Q

______ affects rate of disintegration in Disintegrating Agents

A

Concentration

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15
Q

Prevent the formulation and formed tablet

from sticking to machinery

A

Lubricants

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16
Q

more efficient lubricants are water _____

A

insoluble

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17
Q

Improves flowability of powders/granulation.
Allows formulation to flow easily through tableting
machine

A

Glidants

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18
Q

In Glidants, flowability is measured using angle of ___ or

____

A

repose

Flowdex

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19
Q

Flavors and Sweeteners

A

Sprayed dried and other flavors
Natural sweeteners
Artificial sweeteners

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20
Q

Primary reason for using colors: ______

A

Marketing

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21
Q

Colors used

A

FD&C dyes
FD&C lakes
Iron oxides

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22
Q

Methods of Tablet Preparation

A

Direct compression
Wet granulation
Lugging (dry granulation)
Novel methods

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23
Q

the following are examples of novel method:

A

Fluid bed processing

Hot melt extrusion

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24
Q

Must be a free-flowing and compressible

formulation

A

direct compression

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25
Q

Improve compressibility, flowability, and

content uniformity of powder blend

A

Wet Granulation

26
Q

Direct Compression may require ___ to improve flowability.
Problems with high dose drugs: ____
Problems with low dose drugs: ____

A

glidant
Compressibility
Uniformity

27
Q

Improves compressibility, flowability, and content uniformity of powder blend

A

Wet granulation

28
Q

Stainless steel chamber
Airflow causes continual movement
More efficient drying
Use apparatus to wet granulate and dry

A

Fluidized bed dryer

29
Q

characteristics of Wet Granulation

A 
Good for poor compressible powders
Excellent flow
Good content uniformity
Stability problems
Possible problems with disintegration
Less sensitive to over-blended lubrication
30
Q

What are the things in common between Wet granulation and direct compression

A

blending
premix
compression

31
Q

Comparison of the Two Processes: wet granulation and direct compression

A

Direct Compression

  • Faster dissolution
  • Lower levels of disintegrants needed
  • Increased cost of raw materials

Wet Granulation

  • Produce harder tablets
  • Slower dissolution
  • Cost of equipment, time, labor, and energy
32
Q

Which method does the following:
Compacts large masses of powder mixture
Crush and size pieces into smaller granules

A

Dry Granulation Method

Slugging

33
Q

Properties of Good Tablets

A
  • Physical Stability
  • Chemical Stability
  • Esthetic Appearance
  • Bioavailability
  • Weight and Content Uniformity
34
Q

What is meant by Esthetic Appearance

A

Free of chips/cracks,
contamination, uneven
coloration

35
Q

What is meant by Physical Stability

A

Remain whole during
manufacture/transport/
dispensing

36
Q

Problems in Tableting

A 
Capping
Improper fill
Picking or sticking 
Crumbling
Mottled tablets
Non-disintegrating tablets
37
Q

In-Vitro Tests of Finished Tablets

A 
Content uniformity
Weight uniformity 
Tablet density and or diameter
Hardness 
Friability 
Disintegration
Dissolution
38
Q

this type of testing does the following:
Operates by reciprocating action
A basket-rack device
Records time for disintegration

A

USP Disintegration Testing

39
Q

Factors Affecting Disintegration

A

Addition of disintegrants
Manufacturing method
Pressure used for compression
Tablet hardness

40
Q

A Round bottom flasks containing dissolution

media at 37C

A

USP Apparatus I (Basket) and II (Paddle)

41
Q

In order to Pass the Dissolution Test, All six tablets dissolved at a value that is some % of the total dose, this is called

A

Q-value

42
Q

Other Official Dissolution

Methods

A

USP method III, IV, V-VII,

43
Q

Factors Affecting Dissolution

A 
Particle size
Solubility of drug in solvent 
Ph of solvent
Rate of mixing 
temperature of media
Excipients in formulation
44
Q

Reasons for multiple compression tablets?

A

Separate incompatible components
Make each layer release at a different rate
Make each layer different color

45
Q

Compressed tablets designed to be chewed.
Critical considerations in formulation-
Organoleptic properties

A

Chewable Tablets

46
Q

Tablets designed to dissolve or disintegrate in

mouth in second

A

Fast-Dissolving Tablets

47
Q

advantages of Fast-Dissolving Tablets

A

Good for people who have difficulty swallowing

48
Q

disadvantages of Fast-Dissolving Tablets

A

Tablet is generally weak

Moisture sensitive

49
Q

Reasons for using Buccal and Sublingual Tablets as delivery route?

A

drug destroyed by gastric fluid
drug poorly absorbed from GI tract
achieve rapid absorption (SL Nitroglycerin)

50
Q

____ Used to produce

‘chocolate’ color

A

iron-oxides

51
Q

Used to deliver anti-infective agents or hormones
Inserts Dispensed with applicator
Compressed tablets

A

Vaginal tablets

52
Q

Effervescent Tablets advantages

A

Rapid disintegration
No dissolution problems
Mask taste

53
Q

Effervescent Tablets disadvantages

A

Expensive
High sodium conc
Packaged in hermetically sealed containers
Special production facility

54
Q

Tablet Triturates

A
  • rapidly dissolved in water
  • contain a small amount of potent drug, lactose or
    sucrose as filler
  • fragile tablets
55
Q

____ Tablets are Compress effervescent salts

A

Effervescent

56
Q

some excipients required for effervescent tablets

A

Binders
Lubricants
Flavors/sweeteners

57
Q

Acids used in effervescent tablets

A

citric acid

tartaric acid

58
Q

salt used in effervescent tablets

A

bicarbonate

59
Q

Official dissolution methods:
Reciprocating cylinder apparatus-
Flow through cell-
Transdermal patches-

A

USP method III
IV
V-VII

60
Q

Examples of disintegrating agents

A

Starch and starch derivatives - croscarmellose starch and sodium starch glycolate

61
Q

Examples of lubricants

A

Magnesium stearate*

Talc

62
Q

Examples of glidants

A

Silica derivatives

Talc

Ceutics- packet 1 (6 decks)

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