T41g Mood stabilizers

Question 1

Amphetamines

Answer 1

psychostimulant. interfer with ability of synaptic vesicles to store monoamine. displace 5HT, DA, NE from storage vessicle increasing NE in prefrontal cortex. and inhibit monoamine oxidase.

ADV. drug of abuse

Question 2

Atomoxetine

Answer 2

mood stabilizer. psychostimulant. selective NE reuptake inhibitor (increased NE in prefrontal cortex)

TX. ADHD

ADV cardiotoxicity. withdrawl could lead to suicidal (Taper), rare liver tox, less insomnia

Question 3

Cocaine

Answer 3

psychostimulant. block reuptake (5HT, NE, DA), NA chanel blocker

ADV. drug of abuse. Tox vasoconstriction, mydriasis,

Withdrawl. depression

Question 4

Dextroamphetamine

Answer 4

psychostimulant. interfer with ability of synaptic vesicles to store monoamine. displace 5HT, DA, NE from storage vessicle increasing NE in prefrontal cortex.

DOA: D isomer of amphetamine (similar to cocaine, noncathoaminergic)

Question 5

Lithium carbonate

Answer 5

bipolar drug of choice. prevents recycling of inositol (decreasing PIP2 (Gq) and decreasing cAMP (Gs.i) )

DOA: narrow therapeutic index. similar to sodium (depolorize cells causing seizures)

TX. bipolar DOC. usually with antidepressant/antipsychotic in mania

ADV. seizures, endocrine (hypothyroidism TSH-Gs, peripheral deiodinase inhibitor thereby increasing depression), nephrogenic diabetes insipidus (nephro ADH-Gs) do not use thiazide which would cause increase lithium (sodium ike) therefor use amiloride or triampterien. teratogen epsteins anomoly.

Question 6

Methylphenidate

Answer 6

Mood stabilizer. amphetamine-like (ritalin/concerta). causes downregulation of neurotransmitter.

TX. ADHD

ADV: agitation, restlessness, insomnia, cardiovacular toxicity (high NE). withdrawl could lead to suicidal (Taper)

Question 7

Modafinil

Answer 7

psychostimulant. MoA unclear causes euphoria without abuse.

Tx. narcolepsy