Protein Synthesis Inhibitors

Question 1

Tetracycline

Answer 1

Demeclocycline, Doxycycline, Miocycline

Bind 30s ribosomal subunit and inhibiting binding of tRNA to mRNA. inability to add amino acids to proteins.

broad spectrum

Resistance: enzamativ inactivation, decreased uptake, ribosomal protective proteins.

• Bacillus antracis (+)
• brucella spp (-)
• vibrio cholera (-)
• Yersinia estis (-)