T2DM Flashcards
types of T2DM medication
Biguanides–> metformin
Sulphonyureas–> Glicazide
Glitazones (thiazolidinediones)–> Pioglitazone
Gliflozins (SGLT2 inhibitors)–> Canaflozin
Gliptins (DDP-4 inhibitors) —> Saxagliptin
GLP receptor analogues –> Exenatide
name a sulphonylureas
glicazide
name a biguanide
metformin
name a glitazone (thiazolindinediones)
pioglizatone
name a gliptin (DPP-4 inhibitor)
saxagliptin
name a gliflozin (SGLT-2 inhibitor)
canaflozin
name a GLP-1 receptor agonist (incretin mimic)
Exenatide
glicazide MOA
stimulating pancreatic insulin secretion
metformin (biguanide) MOA
reducing hepatic glucose output by reducing glucoseneogenesis
glitazone MOA
enahnced insulin sensitvity and glucose utilisation
–> stimulates ppar-γ which encourages conversion of glucose –> triglycerides
gliptins MOA
prevent incretin degradation
incretins promote
incretins promote insulin secretion and supress glucagon release
gliflozins
reduce glucose reabsorption
incretin mimimics (GLP-1 receptor agonists) MOA
increase glucose-dependent synthesis of insulin
how are DM medications admistered
all PO bar one which is delivered SC
which DM drug is adminsitered subcutaneouly
exenatide- glucagon-like peptide 1 receptor agonists (incretin mimetics)
protein so would be digested if given enterally
which drugs can cause hypoglycaemia when administered alone
glicazide (sulphonylures) and metformin (biguanides)
which drugs increase appetite
glicazide (sulphonylureas)
which drugs suppress appetite
Glitpins and biguandides
which drug increases satiety
GLP receptor agonists (exenatide)
which drug helps decrease weight
gliflozins (SGLT-2) inhibitors
