T1DM Flashcards
Describe T1DM
Autoimmune condition characterised by pancreatic beta cell destruction and absolute insulin deficiency
What gender is more suseptiable to T1DM?
Males
When does T1DM peak?
Early childhood - 6months-5 years
T1DM can reduce life expectancy by how many years?
11-15 years
How do the side effects of T1DM differ to T2DM?
They are similar but are more severe with faster onset
Profound ymptoms can develop in days/weeks
DKA (Diabetix ketoacidosis) presentation at diagnosis is common and can be fatal
Erectile dysfunction
Anxiety
Depression
Hypoglycaemia
Increased risk of other AI diseases
What are the presenting symptoms of DKA? (Diabetes Ketoacidosis)
Nausea/vomitting
Abdominal pain
dehyration
shortness of breath
List causes and risk factors of T1DM
Genetics Stress Viral infections Obesity Early nutrition - gluten <4 months old/cows milk C-section delievery Nitrates Vitamin D deficency Omega-3 deficiency
What GI inflammatory factor is common in T1DM?
Zonulin
Common bacterial patterns in T1DM are:
reduced firmicutes/bacteroides
What are 2 signs that gut dysbiosis is a causitive factor of T1DM that may be found on a GI test?
Raised zonulin levels
Reduces firmicutes and bacteroides
List naturopathic approaches to T1DM
Support blood glucose levels -low gI meals -avoid high refined carbhydrates, alcohol, concerntrated sugars such as fructose, nitrates -increase high fibre foods Restore nutrient deficencies Optimise gut health Reduce stress Support exercie Support sleep Reduce inflammation Remove llaergens
What tea can help immune modulation and reduce immune mediated damage to B-cells and what is the component?
Green tea. Epicatechins
What is one thing that may help delay or reverse beta cell damage?
Early intervention, the honeyoon period
List nutrients/supplements useful for T1DM support and their dosage
Alpha lipoic acid 400-800mg
EPA-DHE - 1-4g
Vitamin D - 2000IU - more if deficent
Vitamin C - 2-3g
How is Vitamin C useful in T1DM?
Reduces oxidative stress and inflammation
Reduces sorbitol
Hot can vitamin D support T1DM?
Improves insulin production
Improves islet cell survical
Immunoregulatory
How is ALA helpful in T1DM?
Antioxidant, reduces inflammation
How is EPA and DHA useful in T1DM?
REduces inflammation
protets cell membranes
linked to T1DM development during pregnancy
What deficiency is linked to T1DM development during pregnancy?
Vitamin C
