T1 Flashcards
What is the medication involved in hyperplasia of connective tissue is related to gingival hyperplasia?
Phenytoin (dilantin)
What is CXCL8?
Chemokine that is secreted by macrophage when it is activated and it recruits other cells - specifically neutrophils!
What is IL-12?
Recruits and activates NK cells; secreted from activated macrophage
What are the pro-inflammatory cytokines?
IL-1, IL-6, IL-12, IL-17
TNF-a
IFN-y
CXCL8
What are the anti-inflammatory cytokines?
IL-4, IL-10, IL-22
TGF-b
Only cytokine to shut off venous return:
TNF-a
nTreg cells are developed in the thymus because they’re bound to:
Hassell’s corpuscles
nTreg = \_\_ tolerance iTreg = \_\_ tolerance
nTreg = thymic tolerance iTreg = peripheral tolerance
Treg cells are regulatory cells that are present to:
suppress other T cells because the immune system might cause too much damage
What is the function of CCL18?
Recruit naive T cells to the lymph node to bind to the dendritic cells that have done antigen processing
The part of the pathogen to which the antibody binds is the antigenic determinant
Epitope
Storage form of iron:
Hemosiderin
Dendritic cells can activate T cells because they express:
B7
What is the transcription factor that drives Th1 T cell differentiation?
T-Bet
What cytokines are used by CD8 T cells to induce apoptosis?
Fas/FasL
What cytokine is secreted by DC to recruit naive T cells?
CCL18
Variability in the Class 1 = ?
heavy chain
Variability in the Class 2 = ?
beta chain
Affinity occurs in the ___ side, avidity occurs in the ___ side.
Affinity = cortical Avidity = medullary
T cell activation occurs in the __
paracortex
Naive T & B cells come in and out of circulation through:
HEV
___ on the T-cell binds to ICAM on the dendritic cells
LFA-1
T cell binds to the HLA via phosphorylation, this is the:
critical step
CD3 signals cause conformational change in LFA-1, so:
rolling stops
CD28 binds to __ on dendritic cells
B7
Resting T cell has __
L-selectin
L-selectin binds to:
S-Lex on resting epithelium
L-selectin becomes:
VLA-4
c5a, c3a =
anaphylaxis
Hyalinized appearing eosinophilic staining encircling blood vessels is called:
fibrinoid necrosis
If you have prolonged GERD that is left untreated, you can get:
Barrett’s Metaplasia
___ can sometimes be precancerous, such as in the oral cavity.
Hyperplasia
Is hydronic swelling reversible?
Yes
Apoptosis is regulated by what family proteins?
BCL-2 family and p53 (guardian of genome)
