T cell Functions

Question 1

What are the roles of the CD4 cells: TH1, TH2, and TH17/Treg?

Answer 1

TH1 -> goes to site of infection
TH2 -> stay in lymph nodes & activate B cells
TH17, Treg -> shows up if the infection doesn’t go away

Question 2

TGF-B is a __ cytokine.

Answer 2

TH2

Question 3

What is the transcription factor for TH17?

Answer 3

RORc

Question 4

What is the transcription factor for iTreg?

Answer 4

Foxp3

Question 5

What CD4 is bound to Hassell’s Corpuscles?

Answer 5

nTreg

Question 6

TGF-B + IL-6 = ?

Answer 6

TH17

Question 7

What happens to patients who take Xeljanz?

Answer 7

Patients don’t get enough TH1 T cell, so the patients will be weak to fight off infections

Question 8

What are the cytokines released by CD8 T cells?

Answer 8

IFN-y
LT
IL-2

Question 9

What are the cytokines released by TH2 cells

Answer 9

IL-4
IL-5
IL-10
IL-13
TGF-B

Question 10

What are the TH1 effector functions? (5)

Answer 10

• Activation and destruction of macrophages
• Isotype switching to IgG
• Alterations in MHC 1
• Increased functions of NK and neutrophils

Question 11

Macrophages, once activated, release:

Answer 11

Reactive oxygen species
Receptors
Cytokines
Lysozyme

Question 12

TH1 makes IFN-y.

IFN-y + ___ = fully functional macrophage

Answer 12

IFN-y + CD40 = fully functional macrophage

Question 13

IL-17, IL-21, and IL-23 = ?

Answer 13

Pro-inflammatory

Question 14

IL-22 = ?

Answer 14

Anti-inflammatory

Question 15

IBD, Fungal infections

Answer 15

IL-23

Question 16

Massive inflammatory response, fungal infections

Answer 16

IL-17

Question 17

How do CD8 T cells tell cells with intracellular pathogen to die?

Answer 17

• Perforin, then granzyme

- FasL

Question 18

B7 on ___ cell binds to CD28 on ___.

Answer 18

B7 = dendritic cell
CD28 = T cell

Question 19

Pathway that uses complement but not CD8 T cells

Answer 19

Extracellular

Question 20

Pathway that uses CD8 T cells but not complement

Answer 20

Intracellular