Shutting Down Immune Response

Question 1

What factor is the driving force behind shutting down the immune response?

Answer 1

Antigen density

Question 2

Why is it necessary to shut down the immune response?

Answer 2

Macrophages & neutrophils secrete ROS that kill the bacteria but can also harm our own tissue. This is bad, so once the antigen density goes down we need to turn this off.

Question 3

What is idiotype regulation?

Answer 3

Idiotype regulation is where the antibodies bind to other self antibodies to eliminate them; they get taken to the spleen where macrophages will eat them

Question 4

What is the purpose of idiotype regulation?

Answer 4

To get rid of excess antibodies

Question 5

Why are excess antibodies bad?

Answer 5

They end up in the kidneys and can cause problems in the glomerulus. Excess antibodies can also cause rheumatoid fever and heart damage.

Question 6

What cytokines are involved in down regulating the immune response?

Answer 6

IL-4, IL-10, IL-13, TNF-beta

secreted by TH2 cells!

Question 7

What cells are affected by the down regulating cytokines?

Answer 7

Macrophages, CD8, NK, and TH1

Question 8

How does high affinity antibody affect B cell activation?

Answer 8

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