T & NK Neoplasms (CD 2, 4, 5, 7)

Question 1

LGL (large granular lymphocytic)

Answer 1

-T cell LGL= clonal expansion of cytotoxic T cells
-CD3, CD8, CD57
————————————
-Chronic lymphoproliferative disorder of NK cells
- CD56+

Question 2

ATLL (Adult T-cell Leukemia/Lymphoma)

Answer 2

• HTLV-1 (Human T lymphocytic virus type 1)
  -Malignant cells: “Flower cells”
  -Treatment: Interpheron alpha and azidothymidine → efficacy on HTLV-1 virus
  -CD3, CD4, CD25, CCR4

Question 3

Mycoises Fungoides

Answer 3

-Cutaneous T-Cell lymphomas (CTCL)
-MOST COMMON variant of CTCL

Question 4

Sezary Syndrome

Answer 4

-Cutaneous T-Cell lymphomas (CTCL)
-End stage variant of MF (Mycoises Fungoides)
-Erythroderma and circulating Sezary cells
-Convoluted nuclei
-Mature memory T(H) cells
-WORSE than MF

Question 5

Anaplastic Large Cell

Answer 5

-“Wreath Cells”
-t(2;5)
-B symptoms (fever, night sweats, unexplained weight loss)
-ALK+, in younger (better prognosis)
-ALK=, common in older patients
-CD2, CD5, CD30