Acute Lymphoblastic Leukemia (ALL)

Question 1

Most common in? (age)

Answer 1

-Most common in children 2-5 years old

Question 2

Cytochemical stains

Answer 2

-TdT+
-PAS+
CD34

Question 3

Predominant cell type

Answer 3

lymphoblasts (high blast)

Question 4

L1
Small uniform lymphoblasts

Answer 4

-85% of ALL’s
-abnormal lymphs
-small blasts (clefting)
-Small percentage of ALL patients + for Ph’ chromosome
-TdT+
-PAS+

Question 5

L2
Large, pleomorphic lymphoblasts

Answer 5

-TdT+
-PAS+
-abnormal lymphs
-ALL is most common in children
-medium/large cells in adults (cleft/indented)

Question 6

L3
Burkitt’s Lymphoma

Answer 6

-TdT+
-PAS+
-abnormal lymphs
-Large vacuolated blasts
Both B/T from lymphoid-CD34, TdT, HLA-DR

Question 7

C-ALL (Common/childhood acute lymphoblastic leukemias)

Answer 7

-Excess abnormal lymphocytes
- >20% blasts

Question 8

B-ALL (B-Lymphoblastic leukemia)

Answer 8

-Lymphoblasts
-Many abnormal B-lymphocytes
CD34, CD19, CD22, TdT

Question 9

T-ALL (T-lymphoblastic leukemia)

Answer 9

-Lymphoblasts may be seen
-Many abnormal T-lymphocytes
-CD2,3,4,5,7,8, TdT

Question 10

NULL-ALL (non-T/B)

Answer 10

Unclassified lymphoblasts w/o T/B cell markers
-Large granular lymphocytes