Plasma Cell Neoplasms (B cells)

Question 1

Multiple Myeloma

Answer 1

-IgG (most common)/ IgA
-“CRAB”
-Calcium increased (hypercalcemia)
-Renal insufficency
-Anemia
-Bone lesions
-“M” spike in gamma-globulin
Overproduction of Bence Jones protein
-FREE LIGHT CHAINS SEEN IN URINE (kappa/lambda)
-↑ ROULEAUX , ESR

Question 2

Waldenstrom’s Macroglobinemia

Answer 2

-IgM
-LACK lytic bone lesions
-Lymphadenopathy, hepatomegaly, splenomegaly