Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Immunology > T cells 2 Part 2 > Flashcards

T cells 2 Part 2 Flashcards

1
Q

How many dendritic cells can one helper T cell scan in an hour?

A

1000

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

If a helper T cell finds its cognate antigen, what binds the two cells together?

A

adhesion molecules (immunological synapse)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What co-receptor on the helper T cell attaches to the MHC II molecule on the dendritic cell? (during Helper T cell Activation)

A

CD4

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What do CD40L proteins attach to on the dendritic cell in order to lengthen the life of the dendritic cell?

A

CD40 proteins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

How long does complete activation of the helper T cells take?

A

about 4-10 hours

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What do Activated T cells produce that is a positive feedback for division?

A

IL-2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

T/F: Activated helper T cells proliferate about 10,000 new cells in the first week.

A

True

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Do Naive T cells have IL-2 receptors on their surface?

A

No. this allows for the specific T cells needed to be produced by helper T cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

T/F:When a helper T cell proliferates and produces more new cells, the helper T cells being made are all the same.

A

True, they are all specific for the cognate antigen.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Besides for remaining in the blood/lymph providing help to B cells and CTLS, what other job do Helper T cells have?

A

leaving the blood to enter battle sites providing help for soldiers on the front line.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

How do Helper T cells help other cells?

A

cytokines-the communication proteins for the immune system

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What do TNF, IFN-gamma, IL-4, and IL-21 all have in common?

A

They are all cytokines

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What are the 3 major subsets of cytokines?

A

Th1, Th2 and Th17

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Dendritic cells recoginze patterns specific to certain what?

A

types of pathogens

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

TLR4 senses LPS which characteristic of what?

A

Gram-negative bacteria

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

TLR4 senses proteins made by what?

A

certain viruses

17
Q

TLR3 recognizes what?

A

double-stranded RNA

18
Q

TLR2 identifies proteins specific to what?

A

Gram-negative bacteria

19
Q

T/F:Macrophages also recognize distinct patterns

A

True

20
Q

T/F: Different pathogens elicit different cytokines from macrophages and other cells.

A

true

21
Q

Cells from different areas of the body make different combinations of cytokines. What cells sense the specific cytokine response?

A

Dendritic cells

22
Q

T/F: Dendritic cells will display the same co-stimulatory molecules on their surface no matter what type of invader they encounter.

A

False; dendritic cell will display different co-stimulatory molecules on their surface depending on what type of invader it has encountered.

23
Q

When are Th1 helper T cells used?

A

Viral or bacterial attack

24
Q

Th1 helper cells respond with classical cytokines. What are classical cytokines?

A

TNF, IFN-gamma, and IL-2

25
Q

T/F: one goal of Th1 Helper T cells releasing classical cytokines is deactivate infected macrophages and natural killer cells.

A

False; the goal is to activate these cells

26
Q

What keeps the macrophages active?

A

IFN-gamma

27
Q

T/F: one goal of Th1 Helper T cells releasing classical cytokines is to provide help to B cells for antibody production.

A

True

28
Q

What tells B cells to make IgG3?

A

IFN-gamma

29
Q

T/F: one goal of Th1 Helper T cells releasing classical cytokines is for IL-2 to recharge Macrophages.

A

False; the goal is for IL-2 to recharge natural killer cells

30
Q

T/F: one goal of Th1 Helper T cells releasing classical cytokines is for IL-2 to stimulate proliferation of CTLs, NK cells and Th1 cells

A

True

31
Q

What are Th2 Helper T cells good for defending against?

A

parasitic attack or food contaminated with pathogenic bacteria

32
Q

What cytokines illicit a response from Th2 Helper T cells?

A

IL-4, IL-5, and IL-13

33
Q

What is the main goal of Th2 Helper T cells?

A

provide help to B cells for antibody production, especially class switching to IgE

34
Q

T/F: IL-13 stimulates mucus in the intestine.

A

True

35
Q

T/F: IL-4 growth factor causes B cells to make IgA (anitbacterial in the GI).

A

False; this is true of IL-5

36
Q

T/F: IL-5 is the growth factor to proliferate T cells (releasing Th2 cytokines).

A

False; this is true of IL-4

37
Q

T/F: IL-4 is the growth factor for B cells that are making IgE.

A

True

38
Q

What are Th17 Helper T cells good for defending against.

A

Fungal attack

39
Q

T/F: IL-17 recruits massive numbers of macrophages.

A

False; neutrophils

Immunology (6 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions