T cells

Question 1

t cell development

Answer 1

1) lymphocyte lineage and closely related to b cells
2) bone marrow to thymus
3) effector cells or helpers to activate immune response

Question 2

t cell development steps

Answer 2

2) bone marrow of long bones
2) leave a travel to circulatory system
3) in the thymus where additional maturation occurs

Question 3

in the thymus

Answer 3

1) thymic cells communicate with T cells via notch receptor signaling which initiates recombination activating genes
- RAG1 and RAG2
3) TCR gene segments in process similar to VDJ rearrangement found in B cells

Question 4

differential

Answer 4

1) many immature t cells in circulatory system at time of infection

Question 5

TCR

Answer 5

2) RAG1 and RAG2
3- unique to T cells
3) VDJ recombination is similar to the process that makes ABs in B cells
- makes heavy and light chain proteins
4) TCR requires antigen to be presented onMHC1
- CD4 stabilized interactions between TCR and MHC2, CD8 to MHC1
- MHC1 expressed universally, primarily in professional APCs

Question 6

non self antigens

Answer 6

1) TCR recognizes non self
2) additional coreceptors such as LFA-1 and ICAM-1 interact to stabilize the cell-to-cell interaction and begin a cascade that initiates the immune response

Question 7

CD8+ function

Answer 7

1) perforin
2) granules move towards immunological synapse

Question 8

TH1

Answer 8

1) eradicate intracellular pathogens

Question 9

TH2

Answer 9

eradication of extracellular parasites and bacterial infection

Question 10

what do dentists need to know

Answer 10

1)neoplastic conditions associated with T cells are cell common than B cells
2) biopsy