T Cell Regulation Flashcards
what is the overall purpose of T reg cells
restrain the immune system
in the presence of what cytokine will a t cell become a T reg cell
TGFbeta
activated helper T cells secrete which cytokines to activate the immune system
TNF and IFN-y
activated T reg Cells secrete which cytokines to restrain the immune system
TFGbeta and IL-10
what does TFGbeta stand for
transforming growth factor beta
what does TFGbeta do
- binds to receptors on T cells
- reduces proliferation
- reduces CTL killing
what does IL-10 do
- binds to receptors on T cells
- blocks co-stim signals (CD28)
- reduces proliferation
does the intestines produce TGFbeta
yes (the epithelial cells)
TFGbeta does what in the Peyers Patch
causes T cells to become T reg cells
what do T reg cells do in the GI tract
encourage a calmer mucosal immune system
T/F T reg cells prevent allergies
true
For co-stim does the APC present the B7 or CD28
B7
what do very experienced T cells make more and more of
CTLA-4
what does CTLA-4 do
- binds to B7 and blocks CD28
- out competes CD28
what does CTLA-4 have very difficult for the T cell to do
become activated
