Spleen and Intestines

Question 1

What is the purpose of the spleen

Answer 1

to filter blood between artery and vein

Question 2

what in the blood is allowed to enter the spleen

Answer 2

everything

Question 3

at rest what percentage of a cardiac output goes through the spleen

Answer 3

5%

Question 4

how long does it take to screen all the blood in your body by the spleen

Answer 4

30 minutes

Question 5

do lymphatics bring lymph to the spleen

Answer 5

NO

Question 6

what is the main cell type in the marginal sinus of the spleen

Answer 6

Resident Dendritic Cells

Question 7

what do Resident Dendritic Cells do

Answer 7

• display MHC II

- travel to PALS and activate T cells

Question 8

where do T cells go after they have been activated by resident dendritic cells

Answer 8

go to lymphoid follicles to help be cells

Question 9

when blood first enters the spleen where is it diverted to

Answer 9

the marginal sinuses

Question 10

what is the marginal sinus of the spleen loaded with

Answer 10

macrophages

Question 11

eventually the blood in the spleen must filter back to which vessel

Answer 11

splenic vein

Question 12

where do T cells hang out in the spleen

Answer 12

PALS

Question 13

what does PALS stand for

Answer 13

Periarteriolar Lymphoid Sheath

Question 14

where do B cells hang out in the spleen

Answer 14

in an area between the PALS and marginal sinus

Question 15

what is the purpose of the Red Pulp in the spleen

Answer 15

to remove old RBCs and recycle Iron

Question 16

is hemoglobin broken down in the spleen

Answer 16

yes

• globin into AAs
• Heme into bilirubin

Question 17

T/F the spleen holds a large # of monocytes

Answer 17

Ture (to become macrophages or DCs)

Question 18

What is an exampe of a MALT

Answer 18

GALT

Question 19

what is an example of a GALT

Answer 19

Peyers Patch

Question 20

how many Peyers Patches does the typical adult have

Answer 20

200

Question 21

does the Peyers Patch have HEVs

Answer 21

YES

Question 22

does the Peyers Patch have outgoing lymph

Answer 22

YES

Question 23

does the Peyers Patch have incoming lymph

Answer 23

NOOOOOOOO

Question 24

what cell allows antigens into the peyers patch

Answer 24

M cells

Question 25

what does the M stand for in M cell (peyers patch)

Answer 25

Microfold

Question 26

what does the M cell lack that makes it different from Enterocytes

Answer 26

Lack Villi and Mucus

Question 27

is the M cell selective in its antigen it encloses into the peyers patch or general

Answer 27

Specific | -only takes in what can bind to its surface molecules

Question 28

What are the Peyers Patches specialized in making

Answer 28

helper t cells that tell b cells to make IgA antibodies (Th2)

Question 29

in the Peyers patch, what is the main cell type in the area where macrophages can eat antigens and present them

Answer 29

macrophages (most outer layer)

Question 30

in the peyers patch what cells are in the area where FDC can catch and present antigens to B cells

Answer 30

lymphoid follicle | - B cell area

Question 31

what is the main cells in the lymph outflow to the next seconday lymphoid tissue in the peyers patch

Answer 31

activated B cells and T cells

Question 32

what happens to T cells that do not meet their congate antigen

Answer 32

they continue in circulation (every 12-24 hrs) | -die after 6 wks

Question 33

do NAIVE t cells have many adhesion molecules or certain adhesion molecules

Answer 33

MANY

Question 34

do EXPERIENCED t cells express many adhesion molecules or certain adhesion molecules

Answer 34

CERTAIN

Question 35

the adhesion molecules that an experienced t cell express depend on what

Answer 35

where the T cell was activated

Question 36

what adhesion molecule is expressed by experienced T cells from a Peyers Patch

Answer 36

a4b7

Question 37

T/F experienced T cells have restricted travel

Answer 37

True

Question 38

B cells that do no meet their cognate antigen do what

Answer 38

leave the secondary lymphoid organ and continue to circulate

Question 39

experienced b cells tend to settle down where

Answer 39

in the bone marrow and make antibodies