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Immunology Exam #2 > Spleen and Intestines > Flashcards

Spleen and Intestines Flashcards

1
Q

What is the purpose of the spleen

A

to filter blood between artery and vein

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2
Q

what in the blood is allowed to enter the spleen

A

everything

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3
Q

at rest what percentage of a cardiac output goes through the spleen

A

5%

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4
Q

how long does it take to screen all the blood in your body by the spleen

A

30 minutes

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5
Q

do lymphatics bring lymph to the spleen

A

NO

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6
Q

what is the main cell type in the marginal sinus of the spleen

A

Resident Dendritic Cells

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7
Q

what do Resident Dendritic Cells do

A
  • display MHC II

- travel to PALS and activate T cells

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8
Q

where do T cells go after they have been activated by resident dendritic cells

A

go to lymphoid follicles to help be cells

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9
Q

when blood first enters the spleen where is it diverted to

A

the marginal sinuses

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10
Q

what is the marginal sinus of the spleen loaded with

A

macrophages

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11
Q

eventually the blood in the spleen must filter back to which vessel

A

splenic vein

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12
Q

where do T cells hang out in the spleen

A

PALS

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13
Q

what does PALS stand for

A

Periarteriolar Lymphoid Sheath

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14
Q

where do B cells hang out in the spleen

A

in an area between the PALS and marginal sinus

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15
Q

what is the purpose of the Red Pulp in the spleen

A

to remove old RBCs and recycle Iron

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16
Q

is hemoglobin broken down in the spleen

A

yes

  • globin into AAs
  • Heme into bilirubin
17
Q

T/F the spleen holds a large # of monocytes

A

Ture (to become macrophages or DCs)

18
Q

What is an exampe of a MALT

A

GALT

19
Q

what is an example of a GALT

A

Peyers Patch

20
Q

how many Peyers Patches does the typical adult have

A

200

21
Q

does the Peyers Patch have HEVs

A

YES

22
Q

does the Peyers Patch have outgoing lymph

A

YES

23
Q

does the Peyers Patch have incoming lymph

A

NOOOOOOOO

24
Q

what cell allows antigens into the peyers patch

A

M cells

25
Q

what does the M stand for in M cell (peyers patch)

A

Microfold

26
Q

what does the M cell lack that makes it different from Enterocytes

A

Lack Villi and Mucus

27
Q

is the M cell selective in its antigen it encloses into the peyers patch or general

A

Specific

-only takes in what can bind to its surface molecules

28
Q

What are the Peyers Patches specialized in making

A

helper t cells that tell b cells to make IgA antibodies (Th2)

29
Q

in the Peyers patch, what is the main cell type in the area where macrophages can eat antigens and present them

A

macrophages (most outer layer)

30
Q

in the peyers patch what cells are in the area where FDC can catch and present antigens to B cells

A

lymphoid follicle

- B cell area

31
Q

what is the main cells in the lymph outflow to the next seconday lymphoid tissue in the peyers patch

A

activated B cells and T cells

32
Q

what happens to T cells that do not meet their congate antigen

A

they continue in circulation (every 12-24 hrs)

-die after 6 wks

33
Q

do NAIVE t cells have many adhesion molecules or certain adhesion molecules

A

MANY

34
Q

do EXPERIENCED t cells express many adhesion molecules or certain adhesion molecules

A

CERTAIN

35
Q

the adhesion molecules that an experienced t cell express depend on what

A

where the T cell was activated

36
Q

what adhesion molecule is expressed by experienced T cells from a Peyers Patch

A

a4b7

37
Q

T/F experienced T cells have restricted travel

A

True

38
Q

B cells that do no meet their cognate antigen do what

A

leave the secondary lymphoid organ and continue to circulate

39
Q

experienced b cells tend to settle down where

A

in the bone marrow and make antibodies

Immunology Exam #2 (7 decks)

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