Secondary Lymphoid Organs

Question 1

What are the 2 primary lymphoid organs

Answer 1

Bone marrow

Thymus

Question 2

where do B and T cells originate

Answer 2

Bone Marrow

Question 3

where does the T cells develop

Answer 3

Thymus

Question 4

What are the secondary Lymphoid organs

Answer 4

Lymph Nodes
Spleen
MALT

Question 5

what does MALT stand for

Answer 5

Mucosal-Associated lymphoid tissue

Question 6

Which lymphoid organs are Lymphoid follicles associated with

Answer 6

all of them

Question 7

what is the make up of a primary lymphoid follicle

Answer 7

• loose network of FDCs

- rich in naive B cells (or memory cells)

Question 8

what does FDC stand for

Answer 8

Follicular Dendritic Cells

Question 9

what is the make up of a secondary lymphoid follicle

Answer 9

• after antigen stimulation

- turns into a Germinal Center

Question 10

Where are dendritic cells made

Answer 10

in the bone marrow and migrate to tissues

Question 11

which cells are APC

Answer 11

B-cells, Macrophages, Dendritic Cells

Question 12

Who do FDCs present their “caught” antigen to

Answer 12

B-cells

Question 13

What binds to invaders so DCs recognize the antigen

Answer 13

Complement proteins and antibodies

Question 14

FDCs have receptors that bind to what

Answer 14

• complement proteins

- FC region of antibodies

Question 15

how does the FDCs make a signal strong enough to activate a B cell

Answer 15

they cluster their opsonized antigens together

Question 16

What causes a Follicle to turn into a Germinal Center

Answer 16

B cells activate and proliferate (doubling every 6 hours) creating a dark zone

Question 17

When some B cells in the germinal center decide to become plasma cells where do they go

Answer 17

Bone Marrow

Question 18

what process allows B cells to fine tune the Fab regions of their antibodies

Answer 18

Somatic Hypermutation

Question 19

New mutations of B cells in the germinal centers are tested where

Answer 19

in the Light Zone

Question 20

class switching of antibodies in the germinal center are likely to occur where

Answer 20

in the Dark Zone

Question 21

T/F secondary lymphoid organs do not have seperate areas for naive T cells and naive B cells

Answer 21

False

Question 22

once Helper T cells are activated they migrate where

Answer 22

the to B cell area to help activate the B cells

Question 23

How can antigens enter lymph nodes

Answer 23

the blood or lymph

Question 24

how do lymphocytes leave the blood and enter the lymph node

Answer 24

via HEV

Question 25

what does HEV stand for

Answer 25

High Endothelial Venules

Question 26

In lymph nodes, what is the major cell type in the Marginal Sinus

Answer 26

macrophages (APC)

Question 27

In lymph nodes, what is the major cell type in the Cortex

Answer 27

• lymphoid follicle

- B cell area

Question 28

in the lymph node, what is the major cell type in the paracortex

Answer 28

T cell

Question 29

why are normal blood vessel endothelial cells difficult for Lymphocytes to pass through

Answer 29

they are overlaped liked shingles and offer less room for passage

Question 30

why are HEVs easy for lymphocytes to pass through

Answer 30

they are columnar and offer more room for passage