Cytokine Profiles

Question 1

What is the function of Dendritic Cells

Answer 1

1. use PRRs to recognize PAMPs on invaders

2. use cytokines from local area to be a “sonar” for T cells

Question 2

T/F Cytokines released from DC cells tell T cells to express specific Cytokines

Answer 2

True

Question 3

what are the 3 different cytokine profiles

Answer 3

Th1
Th2
Th17

Question 4

what are the classic cytokines emitted by a Th1 T cell

Answer 4

TNF, IFN-y, IL-2

Question 5

which cells do the Th1 cytokine profile activate

Answer 5

macrophages and NKCs

Question 6

IFN-y tells B-cells to make which antibody

Answer 6

IGG

Question 7

what is the reason a T cell would express Th1

Answer 7

to induce apoptosis on Bacteria or Virus infected host

Question 8

Where are Th2 cytokine profiles normally expressed in the body

Answer 8

intestines

Question 9

what are the cytokines associated with Th2 cytokine profile

Answer 9

IL-4, IL-5, IL-13, IL-10

Question 10

which antibody does IL-4 tell b cells to make

Answer 10

IGE (to attack parasites in the intestines)

Question 11

which antibody does IL-5 tell b cells to make

Answer 11

IGA (for the mucus membranes in the intestines)

Question 12

what is the purpose of IL-10

Answer 12

to inhibit Th1 cytokine profile cells (to inhibit inflammation in the gut)

Question 13

What are the 2 jobs of the helper t cell

Answer 13

1. remain in blood and lymph and help b cells and CTLs

2. enter battle site providing help for soldiers

Question 14

what are the cytokines produced with the Th17 cytokine profile

Answer 14

IL-17, IL-21

Question 15

what does the cytokine IL-17 attract

Answer 15

Neutrophils (for opsinization)

Question 16

What type of microbe is being targeted for with the Th17 cytokine profile

Answer 16

fungus

Question 17

T/F once a t cell has selected a cytokine profile he can later switch to another profile

Answer 17

False ( committed and limited range)

Question 18

what is one benefit to having specific cytokines for a specific area in the body

Answer 18

so multiple immune responses can happen simultaneously

Question 19

What are Superantigens

Answer 19

viruses and bacterial proteins that bind to specific regions of TCRs and class II MHCs

Question 20

What is the purpose of Superantigens

Answer 20

to produce lots of cytokines (unregulated) and inappropriately activate t cells

Question 21

How many signals does it take to activate Killer T cells

Answer 21

1

Question 22

what is the signal coming from that can activate a Killer T cell

Answer 22

an activated Dendritic cell

Question 23

What does CTL stand for

Answer 23

Cytotoxic T Cell | Killer T Cell | CD 8

Question 24

T/F when the activated DC, CTL and Helper T cell get together their response is much greater

Answer 24

True

Question 25

What are the 2 methods that Killer T Cells kill

Answer 25

1. Perforin

2. Fas Ligand

Question 26

what does perforin do when emitted from a killer t cell

Answer 26

poke a hole in the target cells membrane

Question 27

What does Granzyme B do when emitted from a Killer T Cell

Answer 27

initiates a chain reaction leading to target cell apoptosis

Question 28

Does the CTL have the fas ligand or the fas protein

Answer 28

The Fas Ligand

Question 29

What does the Fas protein on the target cell do when its “activated”

Answer 29

causes the cell to commit suicide

Question 30

what is the co-receptor on a helper t cell

Answer 30

CD4

Question 31

what is the co-receptor on the killer t cell

Answer 31

CD8

Question 32

what is the co stimulator for helper t and killer t cells

Answer 32

B7 and CD28