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Immunology 3 > T cell recognition > Flashcards

T cell recognition Flashcards

exam 3

1
Q

trans-membrane structure, two chain, variable and constant regions

A

TCR

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2
Q

TCR always expressed on the surface expressed with _____ and ________

A

CD3+ and Zeta

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3
Q

signal transduction molecules—> transfer signal from outside to inside and change message into the nucleus

A

CD3+ and Zeta

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4
Q

TCR Short Cytoplasmic tails thus

A

cannot transmit messages

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5
Q

can be used as a marker because it exist on all T cells

A

CD3+

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6
Q

C19/C20 marker for

A

mature B cell

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7
Q

intracellular portion, important for T cell signaling

A

Signaling molecules

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8
Q

this sign says that the gene is expressed

A

+

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9
Q

causes difference in function because their respective function do not overlap

A

alpha/beta and delta/gamma

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10
Q

uptake function by T cells

A

infection, endocytosis and phagocytosis

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11
Q

cell-mediated

A

T cell

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12
Q

humoral

A

AB- B cell

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13
Q

three way interaction between

A

MHC on host cell with peptide derived from antigen with T cell

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14
Q

expressed on all nucleated cells

A

MHC I

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15
Q

expressed constituitively only on antigen presenting cells

A

MHC II

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16
Q

APC cells

A

Dendritic, macrophages and B cells

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17
Q

interact with CD8

A

MHC I

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18
Q

interact with CD4

A

MHC II

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19
Q

coreceptors on alpha/beta TCR t cells

A

CD4 and CD8

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20
Q

specific adhesion molecules and tighten the interaction between t cells and peptide with the host cell

A

CD4 and CD8

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21
Q

they enhance the signal transduction through the TCR

A

CD4 and CD8

22
Q

binds to HIV

A

CD4

23
Q

CD4 and CD8 are not just found in

A

T cells but APC cells as well

24
Q

killer or cytotoxic T cell

A

CD8

25
Q

T helper, cytokine synthesis (Tregs)

A

CD4

26
Q

antigen recognition= TCR

A

alpha/beta and delta/gamma

27
Q

signal transduction

A

CD3 and zeta

28
Q

corereceptor

A

CD4 and CD8

29
Q

T cell development occurs in the

A

thymus

30
Q

where you develop the receptor specific for antigen

A

primary lymphoid organs

31
Q

after puberty what happens to the thymus?

A

shrink and little production of T cells

32
Q

thymus is absent or underdeveloped leading to no mature T cell and thus prone to recurrent infections as a young child

A

Di George

33
Q

developing T cells

A

Thymocytes

34
Q

Common lymphoid progenitor once reaching the thymus is considerd

A

double negative cell

35
Q

double negative cell is

A

not expressing any T cell characteristics

36
Q

gamm/delta do not respond to

A

peptide + MHC

37
Q

bridge between the innate and adaptive response

A

gamma/delta

38
Q

major pathway of the thymus

A

alpha/beta

39
Q

double positive thymocyte expresses both

A

alpha/beta and CD4+ and CD8+

40
Q

process of generating T cell is

A

random

41
Q

site of positive selection

A

cortex

42
Q

site of negative selection

A

medulla

43
Q

in positive selection what is needed for T cells to survive?

A

interaction with my corticol epithelial cells

44
Q

education in positive selection leads to interaction of mature T cells

A

only seen with that MHC that they encountered during development

45
Q

lineage choice leads to expression of either

A

CD4 or CD8 (CD4 is more lucrative 2x over)

46
Q

negative selection explains that for the T cells that survived Positive selection they have to show

A

low affinity for dendritic self cells to survive

47
Q

failure of negative selection

A

autoimmune disease

48
Q

APECED

A

multi-organ system affected

49
Q

a flu hemagglutinin peptide + HLA-DP2

A

CD4 T597

50
Q

an ebola peptide + HLAB3

A

CD8 T1461

51
Q

measles petide + HLADR4

A

CD4 T 8052

52
Q

A flu hemagglutinin peptide + HLA A2

A

CD8 T17

Immunology 3 (5 decks)

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