cell cooperation

Question 1

Binding of cytokine-cytokine receptor interaction includes ___________ of the receptor and activation of ________________

Answer 1

Binding of cytokine-cytokine receptor interaction includes polymerization of the receptor and activation of signal transduction

Question 2

__________ specific for cytokine or receptor can be used to treat autoimmune disease

Answer 2

monoclonal ant

Question 3

subsets of ___________ T cells synthesize different cytokines

Answer 3

CD4+

Question 4

ThI

Answer 4

IFNgamma

Question 5

Th2

Answer 5

IL4, IL5, IL13

Question 6

Th17

Answer 6

IL17

Question 7

Treg

Answer 7

TGF beta and IL10

Question 8

are the CD4+ subsets terminal differentiated? do they inter-convert ?

Answer 8

NO!!

Question 9

innate immune cells produce cytokines that leads to

Answer 9

CD4+ T cell to differentiate

Question 10

CD4+ subsets activate ________ sets of effector cells

Answer 10

different

Question 11

development of Th1 cells start with the

Answer 11

IL12 production

Question 12

Th1 activates the effectors of

Answer 12

CMI

Question 13

Th2 are activated by the production of

Answer 13

IL4

Question 14

Th2 produces

Answer 14

IL5, IL 4 and IL13

Question 15

IL5 activates

Answer 15

eosinophil

Question 16

IL4 and IL13 produce

Answer 16

IgE

Question 17

Th17 is triggered by

Answer 17

fungi and extracellular bacteria

Question 18

Th17 produces

Answer 18

IL17

Question 19

“Pro-inflammatory responses”

Answer 19

IL17

Question 20

nearly all proteins are

Answer 20

thymus dependent antigens

Question 21

what happens in the lymph node?

Answer 21

B cell and T cell interaction (antigen specific on both)

Question 22

first antibody made when B-T interaction

Answer 22

IgM

Question 23

you need this ___________ to help for the germinal center

Answer 23

T cell helpers

Question 24

Products of the germinal center (2)

Answer 24

1. class switched plasma cells

2. Memory B cells

Question 25

IL4 the ig isotype is

Answer 25

IG E

Question 26

IFN gamma ig isotype

Answer 26

IgG3

Question 27

IL4 involved in responses to

Answer 27

allergy and parasites

Question 28

IFN is involved in the activation of the

Answer 28

complement system

Question 29

if there is a defect in either CD154 , CD40 or AID leads to no class switch recombination and this resultes in

Answer 29

Hyper-IgM (HIGM) syndrome

Question 30

______________ do not require T cell help for B cells to synthesize antibody

Answer 30

Thymus-independent antigens

Question 31

TI responses leads to

Answer 31

IgM

Question 32

CD8+ muct be ___________ before they kill their target

Answer 32

activated

Question 33

is the activation in CD8+ separate from killing phase?

Answer 33

Yes

Question 34

Most viruses (like HIV) need __________ to activate CD8+ cells

Answer 34

CD4+ cells

Question 35

Granules in T cells CD8+ punctures the virus by the release of a perforin leading

Answer 35

to a core be formed and granules can storm in and activate apoptosis

Question 36

required for the killing of CD8+ is the need for

Answer 36

the peptide derived from the virus being presented to the MHC I

Question 37

blocking T cell turn off signals

Answer 37

checkpoint therapy

Question 38

genes for new receptor inserted in patients T cells

Answer 38

Engineered chimeric antigen receptor (CAR) T cells

Question 39

Killing B cell tumors expressing

Answer 39

CD19

Question 40

Generation of CAR T cells

Answer 40

isolate T cells, insert CAR genes and infuse back

Question 41

Receptor that compromises a B cell recognition unit and a T-cell signaling unit

Answer 41

CAR T- receptor

Question 42

VH and VL are the variable regions that bind

Answer 42

antigens

Question 43

where do we insert the genes for CAR genes ?

Answer 43

T-cell signaling unit