T-Cell Immunity I Flashcards by P K | Brainscape

Q

Naive T-cell

A

Th0

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Q

Th0 → Th1 directed by _____

A

IL-12/18

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Q

Th0 → Th2 directed by _____

A

IL-4

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Q

Th0 → Treg directed by _____

A

TGF-β

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Q

Th0 → Th17 directed by _____

A

IL-23

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Q

Th0 → ThFH directed by _____

A

IL-6

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Q

Transcription factor, Th0 → Th1

A

T-Bet

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Q

Transcription factor, Th0 → Th2

A

GATA-3

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Q

Transcription factor, Th0 → Treg

A

FOXP3

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Q

Transcription factor, Th0 → Th17

A

ROR

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Q

Transcription factor, Th0 → ThFH

A

Bcl6

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Q

Function, Th1

A

Activates macrophages

Promotes cytotoxic responses by CD8 cells

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Q

Function, Th2

A

Optimal antibody production

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Q

Function, Treg

A

Modulates/suppresses immune responses

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Q

Function, Th17

A

Chronic inflammation

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Q

Function, ThFH

A

Promotes high affinity antibody production in germinal center