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B Cell Immunity Flashcards

1
Q

Three kinds of B-cells

A

B1, conventional B2, marginal zone

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2
Q

B cells with hypermutation

A

Conventional B2 (high hypermutation)

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3
Q

B cells that mediate adaptive immunity

A

Conventional B2

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4
Q

Innate-like B cells

A

B1, marginal zone

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5
Q

B cells with memory development

A

Conventional B2

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6
Q

Self-renewing B cells

A

B1

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7
Q

B cells produced before birth

A

B1

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8
Q

B cells produced after birth

A

Conventional B2, marginal zone B cells

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9
Q

B cells that require T cells

A

Conventional B2

sometimes marginal zone B

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10
Q

Produces more IgG than IgM

A

Conventional B2

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11
Q

High immunogenicity of proteins

A

Large size, subcutaneous > intraperitoneal > IV or intragastric, slow release of adjuvants, multiple differences to self protein

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12
Q

High immunogenicity of proteins

A

Large size, subcutaneous > intraperitoneal > IV or intragastric, slow release of adjuvants, multiple differences to self protein

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13
Q

Adjuvant that enhances immune responses

A

Alum (aluminum hydroxide)

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14
Q

T-independent antigens

A

Polysaccharides (no second signal required)

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15
Q

B-cell stimulatory cytokines after activation of Th cells. Proliferation of B-cells

A

IL-4, 5, 6. Also 10

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16
Q

B-cell stimulatory cytokines after activation of Th cells. Proliferation of B-cells

A

IL-4, 5, 6

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17
Q

Do B cells develop in bone marrow in antigen-dependent or -independent manner?

A

Antigen-independent

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18
Q

What enzyme is required for somatic recombination?

A

AID (activation-induced cytidine deaminase)

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19
Q

IL-4 drives which isotype class switch?

A

IgM to IgG1 and IgE

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20
Q

What are switch sites?

A

Sites upstream of regulatory region that help determine isotype switching

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21
Q

Sites of B cell proliferation and differentiation

A

Germinal center

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22
Q

Define somatic hypermutation

A

Changes in variable region to optimize antibody specificity/diversity

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23
Q

Antibodies predominantly observed with antibody-independent T-cells

A

IgM

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24
Q

CD56

A

NKC

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25
Q

CD56

A

NKC

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26
Q

CD34

A

unique HSC marker

27
Q

CD1A

A

Expressed by cells committed to T-cell lineage after receiving notch signal from DL4 or 1

begin to rearrange TCRgamma, delta and beta genes. Now in pre-T stage

28
Q

Requirements for rearrangement of TCR genes

A

RAG1, RAG2, and IL-7

29
Q

Dark zone

A

Site for somatic hypermutation

30
Q

Light zone

A

Site for class switch recombination and differentiation

31
Q

Light zone

A

Site for class switch recombination and differentiation

32
Q

IL13

A

IgE, Mast cells

33
Q

Hassall’s corpuscles

A

the site for

generation of regulatory T cells

34
Q

IL-17

A

Potent recruited of neutrophils

35
Q

IL-17

A

Potent recruited of neutrophils

36
Q

Humoral immunity

A

ANTIBODIES

37
Q

Humoral immunity

A

ANTIBODIES

humoral = fluid

38
Q

Humoral immunity

A

ANTIBODIES

humoral = fluid

39
Q

TMMI is a host response for ________ pathogens

A

intracellular

40
Q

TMMI is a host response for ________ pathogens

A

intracellular

41
Q

Cardinal cytokine in TMMI response

42
Q

Cardinal cytokine in TMMI response

43
Q

NK cells are sampling which MHC class proteins?

44
Q

How do NK cells kill?

A

Direct cytotoxicity, use of FcR that senses that a specific antibody is bound to cell. Punches a hole with perforin, inserts granzymes to kill cell. Fas-FasL cell (apoptosis)

45
Q

Which cells do no present MHC-II

A

Somatic cells (lungs, gut, etc.)

46
Q

Critical second signal for CD8

47
Q

Critical second signal for CD8

48
Q

Extracellular infections require what type of response

A

B cell response (Th2)

49
Q

Extracellular infections require what type of response

A

B cell response (Th2)

50
Q

Trio of cytokines that activate Th17 immunity

A

IL-6, IL-23, TGF-B

Ratio of IL-6/TGF-B is crucial

51
Q

Trio of cytokines that activate Th17 immunity

A

IL-6, IL-23, TGF-B

Ratio of IL-6/TGF-B is crucial

52
Q

CD80, 86 are also known as

53
Q

CD80, 86 are also known as

54
Q

Treg unique TF

A

CD3, 4, 25+

55
Q

Treg unique TF

A

CD3, 4, 25+ (along with TFG-beta)

56
Q

Treg unique TF

A

CD3, 4, 25+ (along with TFG-beta)

57
Q

Control of CTLA-4 expression

58
Q

Control of CTLA-4 expression

59
Q

During ongoing immune rxns, when TGF-beta becomes more dominant thatn IL-6, Th0 cells are converted to ________ at _________ sites

A

Treg

peripheral (not thymus)

60
Q

During ongoing immune rxns, when TGF-beta becomes more dominant thatn IL-6, Th0 cells are converted to ________ at _________ sites

A

Treg

peripheral (not thymus)

61
Q

Memory CD8 T cells are extremely sensitive to this interleukin

62
Q

Memory CD8 T cells are extremely sensitive to this interleukin

63
Q

CD-4 RM

A

rely on antigen presence

Host defense (9 decks)

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