Systemic Sclerosis

Question 1

50% of patients with scleroderma renal crisis have these antibodies

Answer 1

Anti RNA polymerase

Question 2

Most commonly affected joint in scleroderma MS complications

Answer 2

Hands

Question 3

Cardiac involvement in SSc

Answer 3

Pericardial-
Conduction system fibrosis-
Myocardial fibrosis

Question 4

Antibodies mutually exclusive and specific for SSC

Answer 4

Topoisomerase I (Scl 70)
Centromere

Question 5

Abx Assoc with ILD and poor outcomes

Answer 5

Scl 70

Question 6

Scleroderma antibodies

Associated with PAH

Answer 6

U3 RNP

Question 7

Scleroderma antibodies

Associated with rapidly progressive skin lesions

Answer 7

RNA POL III

Question 8

Scleroderma antibodies

Overlap syndromes

Answer 8

Ku

Question 9

Scleroderma antibodies

Digital ischemic ulcers
Rare renal crisis

Answer 9

Centromere proteins

Question 10

Most common histologic pattern in SSc assoc ILD

Answer 10

Nonspecific interstitial pneumonia

Question 11

Weird thing about ILD in limited cutaneous SSc vs diffuse

Answer 11

Same incidence of Pulmonary arterial hypertension but less have pulmonary fibrosis

Question 12

Most common extracutaneous manifestation of SSc

Answer 12

Raynaud’s phenomenon

Question 13

These skin findings may correlate with pulmonary arterial hypertension in systemic sclerosis patients

Answer 13

Telangiectasias

Question 14

Leading cause of death in systemic sclerosis

Answer 14

Pulmonary

1) ILD
2) Pulmonary vascular disease