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Rheuma > SLE > Flashcards

SLE Flashcards

1
Q

Specific for lupus in high titer may correlate with lupus nephritis

A

DsDNA

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2
Q

Specific for SLE

A

Anti dsDNA antibody

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3
Q

Abx Associated with decreased risk for nephritis

A

Anti ro

Anti la

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4
Q

The most common chronic dermatitis in lupus

A

Discoid lupus erythematosus

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5
Q

The most common pulmonary manifestation of SLE

A

pleuritic with or without pleural effusion

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6
Q

Mainstay of treatment for life threatening manifestations

A

Systemic glucocorticoids

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7
Q

MC pattern of vasculitis not specific for SLE but may indicate active disease

A

leukocytoclastic vasculitis

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8
Q

Antibody assoc with sick syndrome

subacute cutaneous lupus

A

anti Ro

SSA

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9
Q

Antibodies specific for SLE

A

Anti Sm

Anti dsDNA - in high titers

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10
Q

% positivity of ANA in SLE

A

> 98%

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11
Q

SLICC criteria for SLE

A

Presence of 4 criteria (at least one in each category (clinical and immunologic)

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12
Q

clinical part SLICC criteria for SLE

A

Skin
Oral ulcers
Alopecia
Renal

Synovitis
Neuro

< Hemolytic anemia,
Leukopenia,
Thrombocytopenia >

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13
Q

SLICC criteria

immunologic

A 
ANA > reference negative value
Anti dsDNA
Anti Sm
APAS
Low C3
Positive direct coombs test
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14
Q

The most common chronic dermatitis in lupus

A

Discoid lupus erythematosus

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15
Q

Treatment discoid lupus

A

GC

systemic antimalarials

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16
Q

Rx SLE

not life or organ threatening

A

Low dose GC and conservative treatment

if life/ organ threatening: high dose GC, with addition of: MMF or Cyclophosphamide

17
Q

what antibodies do they most likely have? scaly red patches similar to psoriasis or circular flat red rimmed lesions

A

Subacute cutaneous lupus erythemasus

anti Ro antibodies SS-A

18
Q

the most serious manifestation of SLE

A

nephritis

19
Q

Leading causes of mortality in SLE

A

nephritis

infection

20
Q

Most common manifestation of diffuse CNS lupus

A

cognitive dysfunction

21
Q

SLE patients with antibodies to phospholipids risk for _____

A
  1. hypercoagulability

2. acute thrombotic events

22
Q

most common manifestation of SLE

A

pleuritis with or with out pleural effusion

23
Q

Rx SLE pleuritis with or with out pleural effusion

A

NSAIDs

and if severe, GC.

24
Q

MC cardiac manifestation of SLE

A

pericarditis

25
Q

Antibodies in ANA negative lupus

A

anti Ro

anti DNA

26
Q

Used to identify the lupus anticoagulany

A

russel viper venom test

27
Q

Risk for NSAID use in SLE patients

A

NSAID induced aseptic meningitis

28
Q

anti BLys

A

Belimumab

29
Q

Mainstay of treatment for any inflammatory life threatening manifestation

A

systemic GC

30
Q

induction therapy of choice in patients with crescentic lupus nephritis

A

Cyclophosphamide

31
Q

Glucocorticoids that should be used in pregnancy because a placental enzyme, 11 B dehydrogenase 2 inactivates others

A

Dexamethasone

Betamethasone

32
Q

Rx to control SLE in pregnant women

A

Hydroxychloroquine (category D but benefits outweigh the risk) and if necessary prednisone/prednisolone at the lowest effective doses

33
Q

Antibodies to Ro potential problem

A

neonatal heart lo

rash

34
Q

Rx SLE patients with APAS

arterial clotting with repeated metal loses and at least 2 positive tests for APAS

A

Long term anticoagulation
INR 2-2.5 for 1 episode of venous clotting
INR 3-3.5 patients with recurring clots

35
Q

Hemolytic uremic syndrome

A

Hemolysis
Thrombocytopenia
Microvascular thrombosis

36
Q

Rx lupus dermatitis

A

minimise sun exposure
SPF 30
Topical GC and antimalarials
if fail: retinoid acid

37
Q

MC cause of drug induced lupus

A

anti arrhythmics procainamide, disopyramide, propafenone, hydralazine

Rheuma (10 decks)

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