SLE Flashcards
Specific for lupus in high titer may correlate with lupus nephritis
DsDNA
Specific for SLE
Anti dsDNA antibody
Abx Associated with decreased risk for nephritis
Anti ro
Anti la
The most common chronic dermatitis in lupus
Discoid lupus erythematosus
The most common pulmonary manifestation of SLE
pleuritic with or without pleural effusion
Mainstay of treatment for life threatening manifestations
Systemic glucocorticoids
MC pattern of vasculitis not specific for SLE but may indicate active disease
leukocytoclastic vasculitis
Antibody assoc with sick syndrome
subacute cutaneous lupus
anti Ro
SSA
Antibodies specific for SLE
Anti Sm
Anti dsDNA - in high titers
% positivity of ANA in SLE
> 98%
SLICC criteria for SLE
Presence of 4 criteria (at least one in each category (clinical and immunologic)
clinical part SLICC criteria for SLE
Skin
Oral ulcers
Alopecia
Renal
Synovitis
Neuro
< Hemolytic anemia,
Leukopenia,
Thrombocytopenia >
SLICC criteria
immunologic
ANA > reference negative value Anti dsDNA Anti Sm APAS Low C3 Positive direct coombs test
The most common chronic dermatitis in lupus
Discoid lupus erythematosus
Treatment discoid lupus
GC
systemic antimalarials
Rx SLE
not life or organ threatening
Low dose GC and conservative treatment
if life/ organ threatening: high dose GC, with addition of: MMF or Cyclophosphamide
what antibodies do they most likely have? scaly red patches similar to psoriasis or circular flat red rimmed lesions
Subacute cutaneous lupus erythemasus
anti Ro antibodies SS-A
the most serious manifestation of SLE
nephritis
Leading causes of mortality in SLE
nephritis
infection
Most common manifestation of diffuse CNS lupus
cognitive dysfunction
SLE patients with antibodies to phospholipids risk for _____
- hypercoagulability
2. acute thrombotic events
most common manifestation of SLE
pleuritis with or with out pleural effusion
Rx SLE pleuritis with or with out pleural effusion
NSAIDs
and if severe, GC.
MC cardiac manifestation of SLE
pericarditis
