Osteoarthritis Flashcards
1
Q
Genetic mutation that confer high risk of OA
A
Growth differentiation factor 5
2
Q
Most potent risk factor for OA
A
Age
3
Q
2 major factors contributing to the development of OA
A
Joint vulnerability
Joint loading
4
Q
Sine qua non of OA
A
Hyaline articulate cartilage loss
5
Q
Mucin out glycoprotein secreted by synovial fibroblasts
A
Lu ricin
6
Q
Key joint protectors
A
Muscles and tendons that bridge the joint
7
Q
Where earliest changes in OA occur
A
Cartilage
8
Q
2 major molecules in cartilage
A
T2 collagen- provides cartilage its tensile strength
Agree an
9
Q
Impt radiographic hallmark of OA
A
Osteophytes
