Systemic Lupus Erythematosus

Question 1

SLE prototype of human autoimmune diseases is associated with

Answer 1

HLA DR3

Question 2

Chronic Inflammatory autoimmune diseases characterized by presence of (SLE) ____

Answer 2

Antinuclear Antibody (ANA)

Question 3

SLE usual symptoms are

Answer 3

Joint (symmetric arthritis)
Butterfly rashes

Question 4

Most common visceral organ involved in SLE

Answer 4

Kidney

Question 5

Major cause of death

Answer 5

Nephritis

Question 6

Most dangerous lesion

Answer 6

Diffused Renal Proliferation Glomerulonephritis

Question 7

Laboratory Diagnosis for SLE (3)

Answer 7

1. Demonstration of LE Cells
2. Fluorescence Anti Nuclear Antibody (FANA)
3. Indirect Immunofluorescence

Question 8

Detection of neutrophil that engulfed the antibody-coated nucleus of another neutrophil

Answer 8

Demonstration of LE cell

Question 9

Screening test for ANA. It is sensitive but NOT SPECIFIC.

Answer 9

Fluorescence ANA test

Question 10

Benchmark of autoantibodies present in SLE

Answer 10

Indirect Immunofluorescence

Question 11

Substrate used in Indirect Immunofluorescence to detect anti-dsDNA

Answer 11

Crithidia lucillae

Question 12

Crithidia lucillae consist of __________ that aids in the diagnosis of SLE

Answer 12

circular dsDNA

Question 13

Autoantibody present in Peripheral or Homogenous pattern associated in SLE

Answer 13

Anti-dsDNA

Question 14

Autoantibody present in Homogenous pattern associated in Drug-induced SLE

Answer 14

Anti-histone
Anti-DNP

Question 15

Autoantibody present in Coarse speckled pattern associated in

a. SLE
b. Mixed Connective Tissue

Answer 15

Anti-Smith
Anti-RNP

Question 16

Autoantibody present in Fine speckled pattern associated in Sjoren’s Syndrome and SLE

Answer 16

Anti-SS A/Ro
Anti-SS B/La

Question 16

Autoantibody present in Prominent Nucleoli Staining pattern associated in Systemic sclerosis

Answer 16

Anti-nucleolar

Question 17

Autoantibody present in Atypical pattern associated in Systemic sclerosis & scleroderma

Answer 17

Anti-scl-70

Question 18

Autoantibody present in Fine cytoplasmic SPECKLING associated with Polymyositis

Answer 18

Anti-Jo-1

Question 19

Autoantibody present in Discrete speckled associated with CREST Syndrome

Answer 19

Anti-centromere

Question 20

PATTERN FLUORESCENCE:

Uniform staining of nucleus;

Presence of Anti-dsDNA, Anti-Histone, Anti-DNP

Answer 20

Homogenous/Diffuse Pattern

Question 21

PATTERN FLUORESCENCE:

Intense staining on the outline of the nucleus

Presence of Anti-dsDNA

Answer 21

Rim/Outline Pattern

Question 22

PATTERN FLUORESCENCE:

Fine/Coarse speckled staining of nucleus;

Presence of Anti-ENA

Answer 22

Speckled Pattern

Question 23

PATTERN FLUORESCENCE:

Prominent staining of nucleoli

Presence of Anti-RNA, Anti-RNP

Answer 23

Nucleolar Pattern

Question 24

PATTERN FLUORESCENCE:

Numerous Discrete Speckles

Presence of anti-centromere

Answer 24

Centromere Pattern

Question 25

CREST Syndrome stands for

Answer 25

Calcinosis
Reynauds Phenomenon
Esophangeal dysmotility
Sclerodactyly
Telangiectasia

Question 26

Most specific for SLE

Answer 26

Anti-dsDNA antibodies

Question 27

In SLE, serum complement is

INCREASED OR DECREASED

Answer 27

Decreased (Consumed by Immune-complexes)