Rheumatoid Arthritis

Question 1

Rheumatoid arthritis is strongly associated with

Answer 1

HLA-DRB1

Question 1

Autoimmune disease that affects synovial membrane of multiple joints; errosive and affects heart and lungs

Answer 1

Rheumatic Arthritis

Question 2

Rheumatoid arthritis is characterized by the presence of ______ that targets the ___

Answer 2

IgM
Fc portion of IgG

Question 3

Rheumatoid Factor are seen also in

Answer 3

SLE
Hypo/Hypergammaglobulinemia
Chronic Hepatitis

Question 4

It is more specific to RA than RF

Answer 4

Anti-CCP

Question 5

Laboratory Diagnosis for RA that is more sensitive

Answer 5

Latex Test

Question 6

Laboratory Diagnosis for RA that is more specific

Answer 6

Sheep Cell Agglutination Test

Question 7

Also known as Rose Waaler Test

Answer 7

Sheep Cell Waaler Test

Question 8

Also known as Singer and Plotz

Answer 8

Latex Fixation Test

Question 9

Latex Fixation Test:

Titer >80

Answer 9

Positive

Question 10

Latex Fixation Test:

Titer 20-40

Answer 10

Weak Positive

Question 11

Latex Fixation Test:

No agglutination 1:20

Answer 11

Negative

Question 12

From Cohen

Answer 12

SAET

Sensitized Alligator Erythrocyte Test

Question 13

From Bunim and Bloch

Answer 13

Bentonite Flocculation Test

Question 14

Antibody that is most often tested for initial diagnosis of RA; sensitive but not specific

Answer 14

RF

Question 15

Negative Result does not rule out RA

True/False

Answer 15

True

(70-90% negative to RF has RA)

Question 16

Positive result sometimes means that healthy individual may contain RF

True/False

Answer 16

True
(RF is not specific)

Question 17

Methods for RF detection (3)

Answer 17

ELISA
Chemiluminescence Immunoassay
Nephelometric Methods