Systemic Health/Disease Flashcards
What is scabies?
A skin condition caused by parasitic mites that burrow under the skin and cause itching, rashes, and blisters.
Scabies is spread via close contact with infected people or infected linens or towels.
How is scabies typically treated?
Via the application of prescribed topical cream or lotion or via oral medication.
Although scabies will self-resolve, immediate treatment is recommended to minimize spreading.
What symptom do patients with scabies commonly report worsening at night?
Itching.
This symptom is a significant indicator of the condition.
What is molluscum contagiosum?
A cutaneous viral infection that results in small red or skin-colored bumps.
The condition can self-resolve if left untreated.
How can molluscum contagiosum be treated?
Lesions can be removed, or a topical ointment can be prescribed to decrease healing time.
What type of infection is impetigo?
Bacterial in nature, caused by staphylococcus.
Impetigo results in cutaneous blisters of various sizes.
Where are lesions from impetigo frequently located?
On the arms, legs, and face.
What is tinea commonly known as?
Ringworm.
What type of infection is tinea?
A fungal infection of the skin.
Describe the appearance of lesions associated with tinea.
Circular with clear centers.
What are the characteristic features of neurofibromatosis type I?
Iris Lisch nodules, patchy hyperpigmentation of the skin (cafe au-lait spots), small bump-like tumors under the skin (neurofibromas)
Neurofibromatosis type I is also known as Von Recklinghausen disease.
What causes neurofibromatosis type I?
Mutations in neurofibromin
Neurofibromin is a protein that regulates cell growth.
Which systems can be variably involved in neurofibromatosis type I?
Brain, bones, adrenal glands, vasculature
NF-1 can also cause disturbances in puberty and growth.
How does neurofibromatosis type II differ from type I?
NF-2 presents with neurofibromas but not cafe au-lait spots or Lisch nodules
The main manifestation of NF-2 is the development of tumors in the brain.
What is the main manifestation of neurofibromatosis type II?
Development of non-malignant tumors of the brain in the area of cranial nerve VIII (vestibulocochlear nerve)
This can lead to visual symptoms related to posterior subcapsular cataracts.
True or False: Cafe au-lait spots are associated with neurofibromatosis type II.
False
Cafe au-lait spots are characteristic of neurofibromatosis type I.
Fill in the blank: The appearance of _______ is generally not associated with neurofibromatosis type II.
cafe au-lait spots
What visual symptoms can occur in neurofibromatosis type II?
Development of posterior subcapsular cataracts
These cataracts can affect vision.
What are the main roles of blood?
Transporting nutrients, carrying waste products, maintaining homeostasis, serving as a conduit for phagocytes
What percentage of body weight does blood typically comprise?
6-8%
How much blood does the average adult have?
Roughly 4-5 liters
What is the composition of blood?
Plasma and cellular portion
What percentage of blood volume does plasma make up?
50-60%
What is the primary component of plasma?
Water
What percentage of plasma volume is water?
Roughly 91%
What are the key proteins found in plasma?
Albumin, globulins, high density lipoproteins, low density lipoproteins, fibrinogen
What roles do proteins in plasma perform?
Lipid transport, blood clotting, host defense
What other components are dissolved in plasma?
Gases, ions, hormones, sugars, vitamins, amino acids, lipids
What percentage of plasma volume is made up of other dissolved components?
Typically 1%
What is the cellular component of blood composed of?
White blood cells, platelets, red blood cells
What is the role of white blood cells?
Host defense
What is the largest constituent of the cellular portion of blood?
Red blood cells
What is the primary function of red blood cells?
Transport oxygen and carbon dioxide
What is the second largest constituent of the cellular portion of blood?
Platelets
What is the paramount role of platelets?
Clotting
What governs blood type?
Genetics
Blood type is determined by surface proteins on red blood cells.
What are the three variants of surface markers that result in blood types?
A, B, and O
These markers lead to four possible blood types.
What is the characteristic of Type A blood?
Possess A markers, no antibodies against A markers, antibodies against B markers
Individuals with type A blood can receive type A and type O blood.
What blood types can individuals with Type A blood receive?
Type A and Type O
Type O red blood cells do not display any markers.
What is the characteristic of Type B blood?
Possess B markers, antibodies against A markers
Individuals with type B blood can receive type B and type O blood.
What blood types can individuals with Type B blood receive?
Type B and Type O
Individuals with type B blood cannot receive type A blood.
What is the characteristic of Type AB blood?
Possess A and B markers, no antibodies against A or B markers
Considered the universal recipient.
What blood types can individuals with Type AB blood receive?
Type A, Type B, Type AB, and Type O
They will not produce an immune reaction to any type of blood.
What is the characteristic of Type O blood?
No A or B markers, antibodies against both A and B markers
Considered the universal donor.
What blood type is considered the universal donor?
Type O
Individuals with type O blood can only receive type O blood.
What can occur if incompatible blood types are mixed?
Agglutination
Agglutination can lead to blockage of blood vessels causing tissue damage and/or death.
True or False: Type AB blood has antibodies against A and B markers.
False
Individuals with type AB blood do not produce antibodies against A or B markers.
Where else are A, B, and O markers found besides red blood cells?
Saliva and semen
These markers can also be present in other bodily fluids.
What is the Rhesus (Rh) factor?
A marker that may be present on the surface of red blood cells
What does it mean if a person is Rh-?
They do not possess Rh markers on their red blood cells
Why is the Rh factor important in pregnancy?
An Rh- pregnant woman may develop antibodies against an Rh+ fetus
What occurs when an Rh- pregnant woman has an Rh+ fetus?
She will develop antibodies only after the blood types mix
What can cause the mixing of blood types between an Rh- mother and an Rh+ fetus?
Mixing can occur across the placenta or during delivery
What happens if an Rh- woman becomes pregnant again with an Rh+ fetus?
Maternal antibodies enter the fetus’s bloodstream, causing lysis of blood cells
What are the potential consequences of Rh incompatibility during pregnancy?
It can lead to the loss of the fetus
How can Rh incompatibility be treated?
By injecting the mother with Rhogam (anti-Rh gamma globulin)
What is the role of Rhogam in pregnancy?
It inactivates Rh+ antibodies to prevent fetal complications
A positive result in which 3 lab tests would help confirm Reiter’s syndrome?
+ CRP
+ ESR
+ HLA- B27
- Reiter’s syndrome = reactive arthritis due to an infectious process
P wave on EKG
Atrial depolarization (contraction of the atria)
* first wave, lasts for 80ms
QRS complex on EKG
from depolarization of the left and right ventricles
*displays larger amplitude than P wave because ventricles contain more muscles thus creating more powerful contraction
T wave on EKG
Results from recovery of the ventricles
What are patients with bronchitis commonly referred to as?
Blue bloaters
What are patients with emphysema commonly called?
Pink puffers
How does body mass typically differ between patients with bronchitis and emphysema?
Increased in bronchitis, decreased in emphysema
What is the predominant symptom in bronchitis?
Coughing
How does coughing present in emphysema compared to bronchitis?
Intermittently in emphysema, predominant in bronchitis
What is the sputum production like in bronchitis versus emphysema?
Large quantity in bronchitis, rare in emphysema
What is the predominant symptom in emphysema?
Dyspnea (shortness of breath)
When do patients with bronchitis usually experience dyspnea?
Primarily during exercise
How do respiratory infections compare between bronchitis and emphysema?
More frequent in bronchitis
What is the correct order in which inhaled air reaches the lungs?
Nasal cavity
Pharynx (throat)
Larynx (voice box)
Trachea
Bronchi
Lungs
What hormone is secreted by the heart and helps to regulate blood pressure?
Atrial natriuretic hormone (ANH)
* secreted by atria in response to increased fluid volume that is signaled by atrial stretch
*ANH causes kidney to excrete greater quantities of sodium
* also results in vasodilation of blood vessels, leading to decrease in blood pressure
Calcitonin is released by what gland?
Thyroid gland
* this hormone inhibits osteoclast activity in bones and absorption of calcium by the intestines, leading to diminished blood calcium levels
Melatonin is released by what gland?
Pineal gland
* in response to diminished light levels and causes the hypothalamus to ready the body for sleep
What hormone is released by the kidneys and stimulates the production of RBC by bone marrow?
Erythropoietin
Cushing disease is an excess of?
Cortisone
Exophthalmos is most often associated with what systemic condition?
Graves’ disease —> hyperthyroidism
* inflammatory cells proliferate in back of eye, filling orbit and forcing globe forward
* can also infiltrate EOMs causing muscle thickening and redirection of movement leading to diplopia
What is Hodgkin’s disease?
Type of Lymphoma
* 40% of lymphomas
*Reed-Sternberg cells (“owl eyes” nucleus
*commonly presents with enlarged lymph nodes, fever, night sweats and itching
Good prognosis if diagnosed early
What is Osteogenesis Imperfecta (Ol)?
A congenital, autosomal dominant condition characterized by brittle bones.
What causes Osteogenesis Imperfecta?
The production of abnormal type I collagen.
How many subtypes of Osteogenesis Imperfecta are there?
Four subtypes, each with different severities and prognoses.
What are common symptoms of Osteogenesis Imperfecta?
Multiple bone fractures, potential hearing loss at an early age, and a blue hue to the sclera.
Does a cure exist for Osteogenesis Imperfecta?
No, a cure does not exist.
What types of drugs have shown promising results in treating Osteogenesis Imperfecta?
Bisphosphonates and calcium supplements.
What are recommended therapies for Osteogenesis Imperfecta?
Caution with high-impact activities and exercises to build strong muscles and bones.
What surgical interventions may be necessary for Osteogenesis Imperfecta patients?
Leg bones may need to be reinforced with metal rods or braces.
True or False: Patients with Osteogenesis Imperfecta are at higher risk for retinal detachment.
True.
What complications may Osteogenesis Imperfecta patients face due to poor scleral rigidity?
Subdural hematomas and retinal hemorrhages.
Fill in the blank: Osteogenesis Imperfecta is characterized by _______.
[brittle bones]
A blood pressure cuff too small relative to patient’s upper arm will cause blood pressure to be falsely _____
Elevated
* opposite is true, cuff too big will cause falsely low blood pressure reading
