Systemic Flashcards
What happens with acute inflammation
- vasodilation 2. structural changes 3. PMNs
What happens with chronic inflammation
Macrophages, lymphocytes, plasma cells, Tissue destruction, repair.
Granulomatous inflammation
Marked by a large amount of macrophages.
What affects wound healing
decrease blood flow, other infections,
What happens with cell death?
Lack of oxygen and increased anerobic respiration results in increase cellular Na. If this prolongs necrosis will occur.
Necrosis
The death or one or more cells as a result of irreversible damage.
Coagulative necrosis
Occurs with heart attack. The structure is maintained but inside is sad
Liquefactive necrosis
Lungs with fungus.
Caseous Necrosis
TB.
Hypersensitive Reactions
ACID
Type I hypersensitivity
analphyactic. IgE mediates and bind to mast cell for degranulation. Ca binds the next time for increased response. Initial is 5-30 and late 4-6 hours.
Type 2 hypersensitivity
Cell mediated. Occurs with IgG and IgM. Attacks a foreign body but also hurts the own cell.
Type 3 hypersentivity
Immune complex mediated. Antigen/AB complexes. Occurs with lupus. No foreign part.
Type 4 hypersentivity
Delayed. T lymphocytes encounter an antigen and release luekokini leading to macrophage activation.
Systemic Lupis Erythromatosis
SLE. W>M. 30s. Mallar rash. Type 3. Can have dry eye, disc edema, papilledema, etc. ANA+
Rheumatoid Arthritis
W>Ms. 50’s. Synovial shift in morning so pain is worse. Dry eye=aqeuous deficient. ANA and RF+
Scleromalacia perforans
common with RA. Necrotizing scleritis without inflammation.
JIA
W>M. chronic bilateral non-granulomatous anterior uvieits. Can have a low grade fever. ANA+
Sjogren’s Syndrome
Dry mouth, eye, and arthritis. No arthritis in primary.
Sarcoidosis
Middle aged african American women. non-caveating granulomous and increased ACE. Order a lung X-ray if suspect.
SE with Sarcoidosis (The big 6)
- Anterior granulomatous uveitis 2. bells palsy 3. vitritis (cotton balls) 4. vasculitis (candle wax) 5. ON disease 6. Dacroadentitis
Ankylosing spondylitis
M>F. Young. Has a bamboo spin, sacroiliitis, uveitis, and aortic regurgitation. HLAB27 and X ray should be ordered.
Reactive arthritis
M>F. Urethra, uveitis, joint pain. HLA B27.
Psoriatic Arthritis
Sores in synovial fluid so join pain. HLA B27