syphilis

Question 1

is a chronic sexually transmitted disease with varied clinical and pathologic manifestations

Answer 1

syphilis

Question 2

causative spirochete

Answer 2

Treponema pallidum

Question 3

visualized using?

Answer 3

silver stain and immunofluorescence techniques

Question 4

transplacental transmission of T. pallidium and active disease during pregnancy results in

Answer 4

Congenital syphilis

Question 5

are gram-negative corkscrew-shaped bacteria with axial periplasmic flagella wound around a helical protoplasm

Answer 5

Spirochetes

Question 6

treatment

Answer 6

penicillin

Question 7

affecting small vessels with a surrounding plasma cell-rich infiltrate and is a characteristic of all stages of syphilis

Answer 7

proliferative endarteritis

Question 8

have an intense inflammatory infiltrate that includes T-cells, macrophages and plasma cells that surround the bacteria

Answer 8

superficial sites of infection

Question 9

are t micro 1 cells that may activate macrophages and kills the bacteria

Answer 9

CD4+ T cells

Question 10

protein in the outer membrane that accumulates structural diversity during the course of infectionthrough gene conversion

Answer 10

Tprk

Question 11

how long do primary syphilis occurs?

Answer 11

3 weeks after infection

Question 12

clinical signs of primary syphilis

Answer 12

red lesion at the site of treponemal invasion on penis, cervix, vaginal wall or anus

Question 13

the chancre spread from the chancre throughout the body by?

Answer 13

hematologic and lymphatic dissemination

Question 14

clinical signs of the secondary syphilis

Answer 14

painless, superficial lesions, of the skin and mucosal surfaces (palms and soles of the feet)
maculopapular, scaly or pustular
lymphadenopathy, mild fever, malaise and weight loss

Question 15

secondary syphilis occurs?

Answer 15

2-10 weeks after the primary chancre

Question 16

broad based elevated plaques occurring on the anogenital region, inner thighs and axillae

Answer 16

condylomata lata

Question 17

may form on the oral, pharyngeal and genital mucous membranes

Answer 17

silver-gray superficial erosions

Question 18

asymptomatic neurosyphilis occurs to?

Answer 18

8-40% of patients

Question 19

symptomatic neurosyphilis occurs to?

Answer 19

1-2%

Question 20

secondary syphilis last?

Answer 20

last several weeks then the person enters the latent stage of a disease

Question 21

latent period occurs?

Answer 21

5 years or more

Question 22

3 main manifestations of tertiary syphilis

Answer 22

cardiovascular syphilis, neurosyphilis and benign tertiary syphilis

Question 23

In the form of syphilitic aortitis that account for more than 80% of cases of tertiary disease

Answer 23

cardiovascular syphilis

Question 24

the aortitis leads to

Answer 24

slowly progressive dilation of the aortic root and arch which cause aortic valve insufficiency and aneurysms of the proximal aorta

Question 25

maybe symptomatic or asymptomatic

Answer 25

neurosyphilis

Question 26

which account for about 1/3 of neurosyphilis cases

Answer 26

asymptomatic syphilis

Question 27

neurologic symptoms

Answer 27

pleocytosis, elevated protein levels, decreased glucose

Question 28

is characterized by the formation of gummas in bones, skin and the mucous membranes of the upper airway and mouth

Answer 28

benign tertiary syphilis

Question 29

are nodular lesions related to the delayed hypersensitivity to the bacteria

Answer 29

gummas

Question 30

gummas in the skin may produce?

Answer 30

nodular lesions

Question 31

occurs during maternal primary or secondary syphilis

Answer 31

congenital syphilis

Question 32

congenital syphilis occurs

Answer 32

first 2 years of life (infantile syphilis) and occurs late (tardive syphilis)

Question 33

infantile syphilis clinical symptoms

Answer 33

nasal discharge and congestion

Question 34

congenital syphilis clinical signs

Answer 34

hepatomegaly and skeletal abnormalities

Question 35

mainstay for the diagnosis of syphilis

Answer 35

serologic testing

Question 36

serologic testing includes?

Answer 36

nontreponemal antibody test and antitreponemal antibody test

Question 37

measure antibody to cardiolipin

Answer 37

nontreponemal tests

Question 38

tests used for syphilis

Answer 38

enzyme immunoassay test and fluorescent treponemal antibody absorption test