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4. AUBF > Synovial Fluid > Flashcards

Synovial Fluid Flashcards

1
Q

damage to the articular membranes synovial membrane, making the fluid viscous.
produces pain and stiffness in the
joints, collectively referred to as

A

Arthritis

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2
Q

Viscous liquid found in the cavities of the
movable joints.

A

Synovial fluid

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3
Q

Lubrication in the joint

A

Synovial fluid

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4
Q

is secreted by synoviocytes in the
damage to the articular membranes synovial membrane, making the fluid viscous.

A

Hyaluronic acid

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5
Q

SPECIMEN COLLECTION AND HANDLING: needle aspiration

A

Arthrocentesis

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6
Q

Sample Anticoagulant Requirement:

A

Sterile heparinized tube for gram stain and culture
Heparin or EDTA
non-anticoagulant tube for other test
NaF tube for glucose analysis

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7
Q

Color of synovial fluid

A

Colorless to pale yellow

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8
Q

Synovial comes from the word

A

Egg

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9
Q

Deeper yellow indicates as

A

Inflammatory & noninflammatory
effusions

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10
Q

The green color indicates

A

Bacterial infection

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11
Q

Red color indicates

A

Hemorrhagic arthritis

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12
Q

TURBIDITY: Presence of

A

WBC, Synovial cells debris and
fibrin

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13
Q

Can be MILKY indicate a presence of

A

Crystal

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14
Q

Arthritis affects the production of

A

Hyaluronidase

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15
Q

Methods for synovial fluid

A

String test (4-6cm)
Rope (mucin clot test)

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16
Q

ROPE COMPOSITIONS FOR CLOT

A

Synovial + 2-5% acetic acid

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17
Q

REPORTING of rope solid clot

A

Good

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18
Q

Reporting of rope soft clot

A

Fair

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19
Q

Reporting of rope friable clot

A

Low

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20
Q

Reporting of rope no clot

A

Poor

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21
Q

Viscous fluid celcius and mins

A

37C to 5 min

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22
Q

Diluting fluid of cell count

A

Normal saline (0.3%)

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23
Q

stain WBC nuclei

A

Methylene blue

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24
Q

Stain same with csf

A

Differential count:

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25
Q

performed on cytocentrifuged preparations or on thinly smeared slides.

A

Differential count

26
Q

Primary Cell can be seenin Normal Synovial Fluid

A

Mononuclear cells
Monocytes
Macrophages
Synovial tissue

27
Q

IMPORTANT CELLS AND INCLUSIONS SEEN IN SYNOVIAL FLUID

A

Synovial lining cell
LE cells
Reiter cell
RA cells

28
Q

Similar to macrophage, but may be multinucleated,resembling a mesothelial cell

A

Synovial lining cell

29
Q

Neutrophil containing characteristic ingested:
“round body

30
Q

Vacuolated macrophage with ingested neutrophils

A

Reiter cells

31
Q

Neutrophil with dark cytoplasmic granules
containing immune complexes

32
Q

Causes of of Crystal formation

A

Metabolic Disorders
Decreased renalexcretion
Degeneration of cartilage and bone
Injection of Medications such as corticosteroids

33
Q

Synovial Fluid Crystals

A

Monosodium urate
Calcium pyrophospate
Cholesterol
Corticosteroid
Calcium oxalate
Apatite (calcium phosphate)

34
Q

Significance of gout

A

Monosodium urate

35
Q

Significance of pseudogout

A

Calcium pyrophosphate

36
Q

Significance of extracellular

A

Cholesterol

37
Q

Significance of injection

A

Corticosteroids

38
Q

Significance of renal dialysis

A

Calcium oxalate

39
Q

Significance osteoarthritis

A

Apatite (calcium phosphate)

40
Q

Crystal Polarization

A

MSU crystal
CPPD crystal

41
Q

run parallel to the long axis of the crystal

A

MSU crystal

42
Q

run perpendicular to the long axis of the crystal

A

CPPD CRYSTAL

43
Q

Chemical Analyses

A

Protein
Lactate test
Uric acid
Glucose

44
Q

MICROBIOLOGIC TEST used

A

Gram stain
Culture

45
Q

are most frequently seen in microbiology test

A

Bacterial infection

46
Q

The common organisms that infect synovial fluid
are the fastidious:

A

Haemophilus spp. and neisseria gonorrhoeae

47
Q

The common organisms that infect synovial fluid that can occur

A

Fungal, tubercular and viral infections

48
Q

The autoimmune diseases rheumatoid arthritis and lupus erythematosus cause very serious inflammation of the joints and are diagnosed in the serology laboratory by demonstrating the presence of their particular autoantibodies in the patient’s serum.

A

Serological test

49
Q

Serological test demonstration of antibodies to the causative agent _____________ in the patient’s serum can confirm the cause of the arthritis.

A

Borellia burgdorferi

50
Q

demonstration of antibodies to the causative agent Borrelia burgdorferi in the patient’s serum can confirm the cause of the

51
Q

Serological test acute phase reactants

A

fibrinogen and C-reactive protein

52
Q

Clear, yellow fluid
• Good viscosity
• WBCs <1000 μL
• Neutrophils <30%
• Normal glucose (similar to blood
glucose)

A

No inflammatory

53
Q

• Cloudy, yellow fluid
• Poor viscosity
• WBCs 2000–75,000 μL
• Neutrophils >50%
• Decreased glucose level
• Possible autoantibodies present

A

Inflammatory immunologic origin

54
Q

• Cloudyormilkyfluid
• Low viscosity
• WBCs up to 100,000 μL
• Neutrophils<70%
• Decreased glucose level • Crystalspresent

A

Inflammatory Crystal-induced origin

55
Q

• Cloudy,yellow-greenfluid
• Variable viscosity
• WBCs50,000–100,000μL
• Neutrophils>75%
• Decreased glucose level
• PositivecultureandGramstain

56
Q

• Cloudy,redfluid
• Low viscosity
• WBCsequaltoblood
• Neutrophilsequaltoblood • Normalglucoselevel

A

Hemorrhagic

57
Q

Significance of synovial lining cell

58
Q

Significance of le cell

A

Lupus erythematosus

59
Q

Significance of reiter cell

A

Reiter syndrome
Nonspecific inflammation

60
Q

Significance of ra cell

A

Rheumatoid arthritis
Immunologic inflammation

4. AUBF (7 decks)

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