Synaptic Transmission Flashcards
what is a neurotransmitter
a chemical messenger that carries, boosts and modulates signals between neurons and other cells in the body
excitatory neurotransmitters
have excitatory effects on the neuron- increase the likelihood that the neuron will fire an action potential.
- eg noradrenalin in fight or flight
inhibitory neurotransmitters
decrease the likelihood of the neuron firing an action potential.
-eg serotonin in depression
process of synaptic transmission
- an action potential arrives at presynaptic knob in form of electical signal
- vesicles fuse with membrane of presynaptic knob
- neurotransmitters are released where they can diffuse across the synaptic cleft
- neurotransmitters bind with specific receptors found on the outer membrane of post synaptic knob
- if neurotransmitters are excitatory enough they will bind with their receptors and action potential will be fired
- neurotransmitters are recycled by re entering the presynaptic knob via reuptake ports so that process can start again
drug effect on synaptic transmission
1- block the reuptake (increase, SSRI)
2- mimics natural neurtransmitter (increases the amount of neuro transmitters in cleft)
3- block the receptors ( decreases cos body thinks theres already enough)