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Human Physiology Block 1 > Synaptic Transmission > Flashcards

Synaptic Transmission Flashcards

1
Q

Most of the synapses in the body are

A

chemical synapses

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2
Q

where are NTs stored?

A

presynaptic vesicles

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3
Q

narrow space that separates the pre and postsynaptic cell

A

synaptic cleft

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4
Q

contains the postsynaptic receptors

A

postsynaptic densities

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5
Q

excitation-secretion coupling phase time

A

less than 1 ms

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6
Q

recovery phase time

A

less than 1 second

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7
Q

recycling phase time

A

less than 1 min

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8
Q

excitation-secretion coupling phase deals with

A

the Ca influx/exocytosis thing

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9
Q

recovery phase: presynaptic Ca channels close following

A

membrane hyperpolarization

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10
Q

recycling phase: synaptic vesicles which underwent exocytosis are ( )

A

endocytosed

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11
Q

synaptic vesicles are docked at the presynaptic terminal membrane via formation of the ( )

A

SNARE protein complex

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12
Q

Structure of SNARE complex

A

1) syntaxin
2) synaptobrevin
3) SNAP-25

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13
Q

botulism and tetanus are caused bye

A

clostridial toxins

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14
Q

Examples of Amines

A
  • Ach
  • Histamine
  • Serotonin
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15
Q

Examples of Catecholamines

A
  • Dopamine
  • Epinepherine
  • Norepinepherine
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16
Q

Examples of Amino Acids

A
  • Aspartic acid
  • GABA
  • Glutiamic acid
  • Glycine
17
Q

Exmaples of Polypeptides

A
  • Glucagon
  • Insulin
  • Somatostatin
  • Angiotension II
18
Q

Examples of Lipids

A

Endocannabinoids

19
Q

Examples of Gases

A

-Nitric oxide

0Carbon monoxide

20
Q

Major excitatory NT

A

glutamate

21
Q

Major inhibitory NT

A

GABA

22
Q

At the NMJ the most common NT is

A

Ach

23
Q

nicotinic receptor

A

ionotropic (liagand gated)

24
Q

muscarinic receptor

A

metabotropic (G-coupled)

25
Q

Summation of incoming signals in space and time

A

synaptic integration

26
Q

lethal toxin: interfere with synaptic vesicle docking or fusion process

A

clostridium neurotoxins

27
Q

lethal toxin: blocks AchR

A

alpha-bungarotoxin

28
Q

lethal toxin: blocks acetylcholinesterase

A

nerve gas

29
Q

lethal toxin: blocks presynaptic Ca2+ channels

A

w-conotoxin

30
Q

drugs: monoamine reuptake inhibitor

A

cocaine

31
Q

drugs: serotonin reuptake inhibitor

A

anti-depressants (Prozac)

32
Q

drugs: stimulate IPSP by acting on opioid receptors linked to K channel activation

A

opioids (morphine)

33
Q

drugs: presynaptic calcium channel blocker in clinical trials as pain-killer

A

SNX-111 (synthetic analog of w-conotoxin)

Human Physiology Block 1 (15 decks)

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