Sympathomimetics (Indirect Agonists)

Question 1

What does an indirect adrenergic agonist do?

Answer 1

Increases the net release of catecholamines from nerve terminals

Question 2

What does Amphetamine do?

Answer 2

NET substrate and NE reuptake blocker. Its is lipid soluble and is excreted unchanged in urine.

Question 3

What are the uses for Amphetamine? Side effects?

Answer 3

Uses: ADHD and narcolepsy

Side effects: Tachyarrthythmias

Question 4

Where is Tyramine found?

Answer 4

Found in high concentrations in some fermented foods.

Question 5

What is the MOA of Cocaine?

Answer 5

Inhibits Dopamine and NE reuptake

Question 6

What is the MOA of Tricyclic antidepressants?

Answer 6

Imipramine, amitriptyline; Inhibit NET mediated reuptake of NE into presynaptic terminals in the CNS
Side effects: Postural hypotension, sinus tachycardia

Question 7

What is a false neurotransmitter?

Answer 7

An amine that can be stored in and released from presynaptic vesicles but has no effect on postsynaptic receptors.
Side effect: Postural hypotension