G-protein-linked 2nd messengers Flashcards
1
Q
A1
A
Activates Gq;
- Increases smooth muscle contraction
- Increases pupillary dilator muscle (mydriasis)
- Increases intestinal and bladder sphincter muscle contraction
2
Q
A2
A
Activates Gi;
- Sympathetic shut-off
- Decreases insulin release
- Decreases lipolysis
- Decreases aqueous humor production
- Increases platelet aggregation
3
Q
B1
A
Activates Gs;
Increases HR, contractility, renin release and lipolysis
4
Q
B2
A
Activates Gs;
- Increases vaso/bronchodilation, lipolysis, insulin release, and aqeous humor production
- Decreases uterine tone and ciliary muscle relaxation
5
Q
B3
A
Activates Gs;
Increases lipolysis and thermogenesis in skeletal muscle
6
Q
M1
A
Activates Gq;
Affects the CNS and enteric nervous system
7
Q
M2
A
Activates Gi;
Decreases HR and contractility of atria
8
Q
M3
A
Activates Gq;
- Increases exocrine gland secretion (lacrimal, sweat, salivary, gastric acid)
- Increases gut peristalsis, bladder contraction, bronchoconstriction, miosis
9
Q
D1
A
Activates Gs;
1. Relaxes renal vascular smooth muscle
10
Q
D2
A
Activates Gi;
Modulates transmitter release (Especially in brain)
11
Q
H1
A
Activates Gq;
- Increases nasal and bronchial mucus production
- Increases vascular permeability
- Increases contraction of bronchioles
12
Q
H2
A
Activates Gs;
Increases gastric acid secretion
13
Q
V1
A
Activates Gq;
Increases vascular smooth muscle contraction
14
Q
V2
A
Activates Gs;
Increases H2O permeability and reabsorption in collecting tubules in kidneys
