GI Pharmacology

Question 1

What is the MOA of an antacid?

Answer 1

Neutralize HCL secreted by parietal cells

Question 2

What are the key pharmacokinetic properties of Baking soda (Sodium Bicarbonate)

Answer 2

Water Soluble, Rapidly reacts, leaves stomach quickly

Question 3

Adverse effects of Baking soda?

Answer 3

1 .High sodium content is bad for hypertension.

2. Metabolic alkalosis and fluid retention

Question 4

Pharmakinetic properties of Aluminum hydroxide

Answer 4

Low acid neutralizing capacity

Question 5

Adverse effects of aluminum hydroxide

Answer 5

1. Constipation

2. Can build toxicity in CKD patients.

Question 6

Clinical use of aluminum hydroxide

Answer 6

Used in renal failure to bind phosphates in small bowel

Question 7

Name an H2 receptor antagonist

Answer 7

Ranitidine

Question 8

Pharmakinetic properties of Ranitidine

Answer 8

1. Inhibits gastric acid secretion stimulated from histamine, food and CN X.
2. Does NOT lower LES tone or gastric motility

Question 9

Adverse effects of Ranitidine

Answer 9

1. Cimetidine blocks androgen receptors at high doses.
2. Delirium in elderly
3. Tolerance over time

Question 10

Drug-drug interactions of Ranitidine

Answer 10

1. Cimetidine inhibits CYP

2. Affects warfarin

Question 11

Clinical uses of Ranitidine

Answer 11

Ulcer hypersecretory states, Zollinger-Ellison, Reflux esophagitis

Question 12

Name some Proton pump inhibitors

Answer 12

Omeprazole, Lansoprazole, esomeprazole

Question 13

MOA of proton pump inhibitors

Answer 13

Irreversible noncompetitive inhibition of H/K ATPase in gastric parietal cell.

Question 14

Drug-Drug interactions of Omeprazole

Answer 14

Inhibits CYP 2C19 thus, phenytoin, diazepam, clopidogrel

Question 15

Clinical uses of omeprazole

Answer 15

Ulcers, GERD, Zollinger-Ellison