GI Pharmacology 2

Question 1

MOA of Misoprostol

Answer 1

Prostaglandin analog, inhibits acid secretion, stimulates mucous secretion

Question 2

Adverse effects of Misoprostol

Answer 2

Abdominal pain, Uterine contractions

Question 3

MOA of Sucralfate

Answer 3

Increases synthesis of Prostaglandins in gastric mucosa

Question 4

Adverse effects of Sucralfate

Answer 4

Constipation, flatulence

Question 5

MOA of Bismuth Salt

Answer 5

1. Precipitates and binds to ulcer creating a protective barrier
2. Increase mucous and bicarbonate secretion
3. Suppress H. pylori growth

Question 6

Adverse effect of Bismuth Salt

Answer 6

Tongue turns black, stool is dark

Question 7

What is the family, receptor and site of action for Dimehydrinate?

Answer 7

1. Antihistimine
2. Histamine receptor
3. Vomiting center

Question 8

What is the family, receptor and site of action for Metoclopramide?

Answer 8

1. Benzamides/ Dopamine antagonist
2. Dopamine receptor
3. Used for emesis

Question 9

What is the family, receptor and site of action for Ondanestron, Gransetron and Kolasetron?

Answer 9

1. 5-HT antagonist

2. 5-HT

Question 10

What is the family, receptor and site of action for Aprepitant?

Answer 10

Substance P antagonist

Question 11

What is the family, receptor and site of action for Dronabinol and Nabilone?

Answer 11

Cannabinoid receptor agonist