Sympathomimetics Flashcards
Which receptors do albuterol and salmeterol target?
B2 > B1
What are the applications for albuterol and salmeterol?
Albuterol for acute asthma, salmeterol for long-term asthma or COPD control.
Which receptors does dobutamine target?
B1 > B2 > alpha
What are the applications for dobutamine?
heart failure (inotropic > chronotropic), cardiac stress testing
Which receptors does dopamine target?
D1 = D2 > B > alpha
What are the applications for dopamine?
Unstable bradycardia, HF, shock
Which effects of dopamine predominate at high doses?
Inotropic and chronotropic alpha effects
Which receptors does epinephrine target?
B > alpha
What are the applications for epinephrine?
Anaphylaxis, asthma, open-angle glaucoma. Alpha effects predominate at high doses.
Which has stronger B2 action, epi vs. noepi?
Epi is significantly stronger.
Which receptors does isoproterenol target?
B1 = B2
What are the applications for isoproterenol?
Electrophysiologic evaluation of tacharrythmias. Can worsen ischemia.
Which receptors does norepinephrine target?
a1 > a2 > B1
What are the applications for norepinephrine?
Hypotension (septic shock). *Decr renal perfusion.
Which receptors does phenylephrine target?
a1 > a2
What are the applications for phenylephrine?
Hypotension, ocular procedures, rhinitis
How does amphetamine work?
Indirect general agonist, reuptake inhibitor, also releases stored catecholamines
What are the applications for amphetamines?
narcolepsy, obesity, ADHD
How does cocaine work?
Indirect general agonist, reuptake inhibitor
What are the effects of cocaine intox? What is contraindicated?
Vasoconstriction and local anesthesia. NEVER give beta-blockers, will lead to unopposed alpha1 activation and extreme hypertension.
What does ephedrine work?
Indirect general agonist, releases stored catecholamines
What are the applications for ephedrine?
Nasal decongestion, urinary incontinence, hypotension
