G Protein linked second messengers

Question 1

Which receptors are Gs proteins coupled to?

Answer 1

B1, B2, D1, H2, V2

Question 2

Which receptors are Gi proteins coupled to?

Answer 2

a2, M2, D2

Question 3

Which receptors are Gq proteins coupled to?

Answer 3

a1, M1, M3, H1, V1

Question 4

Which sympathetic receptors are G-protein coupled?

Answer 4

alpha1, alpha2, B1, B2

Question 5

What is the effect of activation of alpha 1 receptors? Which G protein is associated?

Answer 5

1) Inc vasc smooth muscle contration
2) Inc pupillary dilator muscle contraction (myriasis)
3) Inc intestinal and bladder sphincter muscle contraction
G protein: Q

Question 6

What is the effect of activation of alpha 2 receptors? Which G protein is associated?

Answer 6

1) Decreased sympathetic outflow
2) Decreased insulin release
3) Decreased lipolysis
4) Inc platelet aggregation
5) Decrease aqueous humor production
G protein: i

Question 7

What is the effect of activation of beta 2 receptors? Which G protein is associated?

Answer 7

1) Vasodilation
2) Bronchoconstriction
3) Inc Lipolysis
4) Inc insulin release
5) Decrease uterine tone (tocolysis)
6) Ciliary muscle contraction
7) Inc aqueous humor production
G protein: S

Question 8

Which of the parasympathetic receptors are G-protein coupled?

Answer 8

M1, M2, and M3

Question 9

What is the effect of activation of M1 receptors? Which G protein is associated?

Answer 9

CNS, enteric nervous system.

G protein: q

Question 10

What is the effect of activation of M2 receptors? Which G protein is associated?

Answer 10

1) Decrease heart rate
2) Decrease contractility of atria
G protein: I

Question 11

What is the effect of activation of M3 receptors? Which G protein is associated?

Answer 11

1) Inc exocrine gland secretion (lac/saliv/gastricacid)
2) Inc gut peristalsis
3) Inc bladder contraction
4) Bronchoconstriction
5) Inc pupillary sphincter muscle contraction (miosis)
6) ciliary muscle contraction (accomodation)
G protein: M3

Question 12

What is the effect of D1 receptor activation? Which G protein is associated?

Answer 12

1) Relaxes renal vascular smooth muscle

G: S

Question 13

What is the effect of B1 receptor activation? Which G protein is associated?

Answer 13

1) Inc heart rate
2) Inc contractility
3) Incr renin release
4) Incr lipolysis
G protein: S

Question 14

What is the effect of D2 receptor activation? Which G protein is associated?

Answer 14

Modulates transmitter release, especially in brain

G protein: i

Question 15

What is the effect of H2 receptor activation? Which G protein is associated?

Answer 15

1) Inc gastric acid secretion

G protein: S

Question 16

What is the effect of H1 receptor activation? Which G protein is associated?

Answer 16

1) Inc nasal and bronchial mucus production
2) Inc vascular permeability
3) Contraction of bronchioles
4) Pruritis, Pain
G protein: Q

Question 17

What is the effect of V1 receptor activation? Which G protein is associated?

Answer 17

Inc vascular smooth muscle contraction

G protein: Q

Question 18

What is the effect of V2 receptor activation? Which G protein is associated?

Answer 18

Inc H2O permeability and reabsorption in collecting tubules of kidney (V2 in the 2 kidneys).
G protein: S