Muscarinic antagonists Flashcards

1
Q

What three muscarinic antagonists act on the eye?

A

atropine, homatropine, tropicamide

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2
Q

What are the effects of atropine, homatropine, and tropicamide?

A

Produce mydriasis and and cycloplegia.

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3
Q

Which organ system is benztropine typically given for?

A

CNS.

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4
Q

What are the applications of benztropine?

A

Parkinson disease, acute dystonia.

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5
Q

Which organ system is glycopyrrolate typically given for?

A

GI, respiratory

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6
Q

What are the applications of glycopyrrolate?

A

IV: pre-op to reduce GI secretions
PO: Drooling, peptic ulcer

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7
Q

Which organ system is hyoscyamine and dicyclomine typically given for?

A

GI

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8
Q

What are the applications of hyoscyamine and dicyclomine?

A

Antispasmodics for IBS.

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9
Q

Which organ system is ipratropium and tiotropium typically given for?

A

Respiratory

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10
Q

What are the applications of ipratropium and tiotropium?

A

COPD, Asthma

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11
Q

Which organ system is oxybutynin, solifenacin, and tolterodine typically given for?

A

GU

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12
Q

What are the applications of oxybutynin, solifenacin, and tolterodine?

A

Reduce bladder spasms and urge urinary incontinence (overactive bladder)

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13
Q

Which organ system is scopalamine typically given for?

A

CNS

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14
Q

What are the applications of scopalamine?

A

Motion sickness.

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15
Q

What is an “urgent” indication for atropine?

A

Bradycardia.

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16
Q

What are the effects of atropine?

A

Eye (pupil dilation and cycloplegia), Airway (decrease in secretions), Stomach (decrease acid secretion), Gut (decrease motility), Bladder (decrease urgency).

17
Q

What is atropine an antidote for?

A

Organophosphate toxicity. Anti-DUMBBeLSS. (Why not E? – skeletal muscle + CNS mediated by N receptors).

18
Q

What are the symptoms of anticholinergic toxicity/overdose?

A

Hot as a hare (inc in temp due to decreased sweating), dry as a bone (dry mouth, dry skin), red as a beet (flushed skin), blind as a bat (cycloplegia), mad as a hatter (disorientation). May cause urinary retention in BPH, hyperthermia in infants.

19
Q

What is gardener’s pupil?

A

Jimson weed/datura –> mydriasis due to anticholinergic effects of plant alkaloids.