Drug reactions - multi-organ

Question 1

Which drugs cause antimuscarinic sx?

Answer 1

atropine, TCAs, H1 blockers, antipsychotics

Question 2

Which drugs cause “disulfiram like rxn”?

Answer 2

Metronidazole, certain cephalosporins, griseofulvin, procarbazine, 1st gen sulfonylureas

Question 3

Which drugs cause nephrotoxicity/ototoxicity?

Answer 3

aminoglycosides, vancomycin, loop diuretics, cisplatin. Cisplatin may respond to amifostine.

Question 4

High yield Cytochrome P450 inducers?

Answer 4

chronic alcohol use, St Johns Wort, Phenytoin, Phenobarbital, Nevirapine, Rifampin, Griseofulvin, Carbamazepine
“Chronic alcoholics steal phen-phen and never refuse greasy carbs”

Question 5

High yield cytochrome p450 substrates?

Answer 5

anti-epileptics, theophylline, warfarin, OCPs (always think when outside)

Question 6

High yield Cytochrome P450 inhibitors?

Answer 6

acute alcohol abuse, Ritonavir, Amiodarone, Cimetidine, Ketoconazole, Sulfonamides, Isoniazid (INH), Grapefruit juice, Quinidine, Macrolides (exc azithro). “AAA RACKS IN GQ Magazine”

Question 7

What are sulfa drugs to be familiar w/?

Answer 7

Probenacid, Furosemide, Acetazolamide, Celecoxib, Thiazides, Sulfa abx, Sulfasalazines, Sulfonylureas (p-FACTSSS).