Sympathomimetic Drugs Flashcards
Cardiac muscle mainly has what type of receptors?
Beta 1
Vascular smooth muscle has mainly what type of adrenergic receptors? (2)
alpha 1
beta 2
Activates both alpha and beta receptors; higher affinity for beta
Epinephrine
In general, alpha receptor activation causes ______.
vasoconstriction
Beta receptor activation causes _______
vasodilation
What receptor activates bronchial smooth muscle?
beta 2
Selective beta 1 adrenergic receptor agonists (dobutamine) are useful for: (4)
treating shock
cardiac arrest
short term heart failure
performing stress tests
What is a selective beta 2 adrenergic drug?
albuterol
What adrenergic receptor type increases blood glucose in the liver?
beta 2
What drug is a selective alpha 1 adrenergic receptor agonist?
phenylephrine
What drug is a potent vasoconstrictor and acts as a decongestant by decreasing the volume of nasal mucosa?
phenylephrine (neosynephrine)
What alpha 2 adrenergic receptor agonist is useful for hypertension and exerts hypotensive effects via CNS?
clonidine
What drug is also used as an eyedrop solution to treat glaucome?
clonidine
What drug inhibits monamine oxidase activity that increases the action of catecholamines by slowing catecholamine degradation and INDIRECTLY act as sympathomimetics?
phenelzine (Nardil)
What MAO is useful in the treatment of depression, due to effects on CNS receptors…selegiline is currently a popular treatment for Parkinson’s Disease (enhances brain dopaminergic tone)?
phenelzine