Sympathomimetic Drugs Flashcards

1
Q

Cardiac muscle mainly has what type of receptors?

A

Beta 1

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2
Q

Vascular smooth muscle has mainly what type of adrenergic receptors? (2)

A

alpha 1

beta 2

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3
Q

Activates both alpha and beta receptors; higher affinity for beta

A

Epinephrine

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4
Q

In general, alpha receptor activation causes ______.

A

vasoconstriction

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5
Q

Beta receptor activation causes _______

A

vasodilation

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6
Q

What receptor activates bronchial smooth muscle?

A

beta 2

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7
Q

Selective beta 1 adrenergic receptor agonists (dobutamine) are useful for: (4)

A

treating shock

cardiac arrest

short term heart failure

performing stress tests

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8
Q

What is a selective beta 2 adrenergic drug?

A

albuterol

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9
Q

What adrenergic receptor type increases blood glucose in the liver?

A

beta 2

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10
Q

What drug is a selective alpha 1 adrenergic receptor agonist?

A

phenylephrine

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11
Q

What drug is a potent vasoconstrictor and acts as a decongestant by decreasing the volume of nasal mucosa?

A

phenylephrine (neosynephrine)

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12
Q

What alpha 2 adrenergic receptor agonist is useful for hypertension and exerts hypotensive effects via CNS?

A

clonidine

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13
Q

What drug is also used as an eyedrop solution to treat glaucome?

A

clonidine

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14
Q

What drug inhibits monamine oxidase activity that increases the action of catecholamines by slowing catecholamine degradation and INDIRECTLY act as sympathomimetics?

A

phenelzine (Nardil)

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15
Q

What MAO is useful in the treatment of depression, due to effects on CNS receptors…selegiline is currently a popular treatment for Parkinson’s Disease (enhances brain dopaminergic tone)?

A

phenelzine

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16
Q

What drug has dangerous side effects include potentially fatal hypertensive crisis if combined improperly with other sympathomimetics or with foods rich in amines (wine, cheese, beer, chocolate, etc.)?

A

phenelzine

17
Q

What drugs bind to re-uptake transporters (NET) and vesicular transporters (VMAT) to cause reverse catecholamine transport…these drugs cause catecholamine release, and are therefore indirectly-acting sympathomimetic drugs?

A

methylphenidate (ritalin and amphetamine)

18
Q

What drug bind to transporters and cause catecholamine release…indirectly-acting sympathomimetics but does not efficiently cross the BBB and has few effects on the CNS?

A

pseudoephedrine

19
Q

What drug is an indirectly acting sympathomimetic and does act on the CNS?

A

methyphenidate

20
Q

What drug was used in cold formulas but was banned by the FDA and olympic committee?

A

pseudoephedrine