Sympatholytic Drugs Flashcards
What drug is a non-selective beta-adrenergic antagonist?
propranolol
- Commonly used in treatment of hypertension, angina
- Decreases cardiac output by reducing both heart rate and the strength of cardiac ventricular contraction
- Inhibits beta1 receptors in the juxtaglomerular region of the kidney, which inhibits the release of renin
propranolol
What drug is contraindicated by asthma (beta 2 receptor inhibition) because it is a non-selective beta drug?
propanolol
What drug is a selective beta 1 antagonist?
metoprolol
What drug is preferred for heart patients with asthma?
metoprolol
What drug is a non selective alpha antagonist?
phentolamine
What drug’s main clinical use is in treatment of pheochromocytoma?
phentolamine
What drug induces severe hypotension and can be used to reverse hypertensive crisis, for example in a patient on MAO inhibitors who consumes too much wine and cheese?
phentolamine
What drug is a selective alpha 1 antagonist useful in treating HTN?
prazosin (Minipress)
What drug’s main side effects are postural hypotension and mild CNS effects including potential headache, dizziness or nausea?
prazosin
What drug is a selective alpha 2 adrenergic antagonist?
yohimbine
What selective alpha 2 antagonist affects the CNS?
yohimbine
What drug binds to the vesicular monoamine transporter (VMAT) and blocks it, thereby blocking vesicular packaging and release of catecholamines?
reserpine (Serpasil)
What drug is an indirectly-acting sympatholytic?
reserpine
What drug has been used for many centuries to treat hypertension, but is not currently used for this application due to severe CNS-related side effects (can strongly induce depression and impaired cognition)?
reserpine
