Neuroeffector Junctions III Flashcards
What will mimic effects of parasympathetic action by activating muscarinic receptors?
directly acting agonists
________ inhibitors of acetylcholinesterase can increase concentration of ACh and prolong lifetime in junction.
Reversible
Inhibitors of acetylcholinesterase are known as what?
indirect acting agonists
Carbamates are _____ ____ ____.
indirect acting agonists
Carbamates are indirect acting agonists and include these drugs: (3)
physostigmine
neostigmine
insecticide
What are direct acting muscarinic acetylcholine receptor agonist drugs? (2)
bethanecol
pilocarpine
Organophosphates are _______ inhibitors of acetylcholinesterase and increase concentration of ACh while prolonging lifetime in the junction.
irreversible
_____ can reverse the effects of irreversible inhibitors such as organophosphates.
Pralidoxime
__________ poisoning leads to STRONG PERSISTANT activation of ALL acetylcholine receptors, with enhanced activity at parasympathetic system due to actions at both ganglia AND muscarinic receptors.
Organophosphate
______ acting agonists have structures similar to acetylcholine.
Direct
_____ acting agonists inhibit acetylcholinesterase.
Indirect
An antimuscarinic drug is _____.
atropine
Increased concentration of junctional ACh competes with muscarinic blockers and surmounts blockade. This drug was successfully used by Mary Walker on patients with myasthenia gravis.
physostigmine
KNOW
________ antagonists of _______ receptors act at the agonist binding site to induce _______ block.
Competitive
muscarinic
surmountable
Many compounds have prominent antimuscarinic side effects. Tricyclic antidepressants, some competitive nicotinic antagonists, histamine blockers (benedryl), some phenothiazines. True or false?
True
